Functional and structural connectivity of frontostriatal circuitry in Autism Spectrum Disorder.
Functional and structural connectivity of frontostriatal circuitry in Autism Spectrum Disorder.
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DOI：
10.3389/fnhum.2013.00430
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发表时间：
2013
影响因子：
2.9
通讯作者：
Balsters JH
中科院分区：
文献类型：
--
作者：
Delmonte S;Gallagher L;O'Hanlon E;McGrath J;Balsters JH
额纹状体回路的异常可能是自闭症谱系障碍（ASD）的两个核心缺陷的基础；社交互动和沟通困难以及兴趣受限和重复行为。虽然有一些研究检查了自闭症谱系障碍中该回路内的连接性，但之前没有研究检查过同一人群内的功能和结构连接性。本研究首次探索了自闭症谱系障碍中额纹状体功能和结构的连接性。 28 名右手白人男性 ASD（17.28 ± 3.57 岁）和 27 名年龄和智商匹配的右手男性对照组（17.15 ± 3.64 岁）参加了这项研究。在排除过度运动和数据质量差的受试者后，对 21 名 ASD 和对照参与者进行静息状态功能连接，并对 22 名 ASD 和 24 名对照参与者进行纤维束描记。在额叶皮层和纹状体之间进行功能连接分析，然后在功能连接显示显着群体差异的区域之间进行纤维束成像。 ASD 组的额叶皮层 [前扣带皮层 (ACC)、额中回 (MFG)、副扣带回 (Pcg) 和眶额皮层 (OFC)] 和纹状体 [伏核 (NAcc) 和尾状核] 区域之间的功能连接性增强。正如之前在同一参与者中报道的那样，ACC 和尾状核之间功能连接的增加与尾状核社会奖励的失活有关。右侧 MFG 和尾状核之间更强的连通性与更高的受限兴趣和重复行为相关，而双边 Pcg 和 NAcc 以及右侧 OFC 和 NAcc 之间的连通性与社交和沟通缺陷呈负相关。尽管每个受试者都可靠地构建了束，但结构连接性没有组间差异。结果与之前报道的 ASD 皮质纹状体功能连接增加一致。
Abnormalities in frontostriatal circuitry potentially underlie the two core deficits in Autism Spectrum Disorder (ASD); social interaction and communication difficulties and restricted interests and repetitive behaviors. Whilst a few studies have examined connectivity within this circuitry in ASD, no previous study has examined both functional and structural connectivity within the same population. The present study provides the first exploration of both functional and structural frontostriatal connectivity in ASD. Twenty-eight right-handed Caucasian male ASD (17.28 ± 3.57 years) and 27 right-handed male, age and IQ matched controls (17.15 ± 3.64 years) took part in the study. Resting state functional connectivity was carried out on 21 ASD and control participants, and tractography was carried out on 22 ASD and 24 control participants, after excluding subjects for excessive motion and poor data quality. Functional connectivity analysis was carried out between the frontal cortex and striatum after which tractography was performed between regions that showed significant group differences in functional connectivity. The ASD group showed increased functional connectivity between regions in the frontal cortex [anterior cingulate cortex (ACC), middle frontal gyrus (MFG), paracingulate gyrus (Pcg) and orbitofrontal cortex (OFC)], and striatum [nucleus accumbens (NAcc) and caudate]. Increased functional connectivity between ACC and caudate was associated with deactivation to social rewards in the caudate, as previously reported in the same participants. Greater connectivity between the right MFG and caudate was associated with higher restricted interests and repetitive behaviors and connectivity between the bilateral Pcg and NAcc, and the right OFC and NAcc, was negatively associated with social and communicative deficits. Although tracts were reliably constructed for each subject, there were no group differences in structural connectivity. Results are in keeping with previously reported increased corticostriatal functional connectivity in ASD.
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影响因子：
3.7
作者：
Bejjani A;O'Neill J;Kim JA;Frew AJ;Yee VW;Ly R;Kitchen C;Salamon N;McCracken JT;Toga AW;Alger JR;Levitt JG
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Levitt JG
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通讯作者：
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