Mast cells and inflammation.
Mast cells and inflammation.
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DOI：
10.1016/j.bbadis.2010.12.014
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Kalogeromitros D
中科院分区：
文献类型：
--
作者：
Theoharides TC;Alysandratos KD;Angelidou A;Delivanis DA;Sismanopoulos N;Zhang B;Asadi S;Vasiadi M;Weng Z;Miniati A;Kalogeromitros D
肥大细胞因其在过敏和过敏反应中的作用以及它们在获得性和先天免疫中的作用而闻名。现在越来越多的证据表明，肥大细胞在炎症性疾病中被非过敏性触发因素激活，如神经肽和细胞因子，通常发挥协同作用，如IL-33。肥大细胞也可以选择性地释放促炎介质而不脱颗粒。其中IL-1诱导IL-6选择性释放，促肾上腺皮质激素释放激素在应激条件下分泌诱导血管内皮生长因子释放。许多炎症性疾病涉及肥大细胞与T细胞的相互作用，如特应性皮炎、牛皮癣和多发性硬化症，这些疾病都因压力而恶化。肥大细胞的差异反应是如何调控的仍未解决。初步证据表明，线粒体功能和动力学控制肥大细胞脱颗粒，但不是选择性释放。最近的研究结果也表明肥大细胞具有免疫调节特性。了解介质的选择性释放可以解释肥大细胞如何参与许多不同的生物过程，以及它们如何发挥免疫刺激和免疫抑制作用。揭示选择性肥大细胞分泌也可以帮助开发独特的肥大细胞抑制剂与新的治疗应用。
Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity. Increasing evidence now implicates mast cells in inflammatory diseases where they are activated by non-allergic triggers, such as neuropeptides and cytokines, often exerting synergistic effects as in the case of IL-33. Mast cells can also release pro-inflammatory mediators selectively without degranulation. In particular, IL-1 induces selective release of IL-6, while corticotropin-releasing hormone secreted under stress induces the release of vascular endothelial growth factor. Many inflammatory diseases involve mast cells in cross-talk with T cells, such as atopic dermatitis, psoriasis and multiple sclerosis, which all worsen by stress. How mast cell differential responses are regulated is still unresolved. Preliminary evidence suggests that mitochondrial function and dynamics control mast cell degranulation, but not selective release. Recent findings also indicate that mast cells have immunomodulatory properties. Understanding selective release of mediators could explain how mast cells participate in numerous diverse biologic processes, and how they exert both immunostimulatory and immunosuppressive actions. Unraveling selective mast cell secretion could also help develop unique mast cell inhibitors with novel therapeutic applications.
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DOI：
10.1007/bf01674391
发表时间：
1995-04-01
期刊：
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
影响因子：
--
作者：
Bugajski, A J;Chlap, Z;Bugajski, J
通讯作者：
Bugajski, J
DOI：
10.1084/jem.20062211
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allakhverdi Z;Comeau MR;Jessup HK;Yoon BR;Brewer A;Chartier S;Paquette N;Ziegler SF;Sarfati M;Delespesse G
通讯作者：
Delespesse G
DOI：
10.1038/nri2782
发表时间：
2010-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
7.3
作者：
BENYON, RC;ROBINSON, C;CHURCH, MK
通讯作者：
CHURCH, MK
影响因子：
15.1
作者：
Ackerman, KD;Stover, A;Baum, A
通讯作者：
Baum, A