Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma.
Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma.
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新型长非编码RNA LINC02820增强TNF信号通路以重塑细胞骨架并增强食管鳞状细胞癌的转移
DOI：
10.1038/s41417-022-00554-2
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发表时间：
2023-02
影响因子：
6.4
通讯作者：
Huang BJ
中科院分区：
文献类型：
--
作者：
Wang J;Huang TJ;Mei Y;Luo FF;Xie DH;Peng LX;Liu BQ;Fan ML;Zhang JB;Zheng ST;Qian CN;Huang BJ
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in China. However, there are no targets to treat ESCC because the molecular mechanism behind the cancer is still unclear. Here, we found a novel long noncoding RNA LINC02820 was upregulated in ESCC and associated with the ESCC clinicopathological stage. Through a series of functional experiments, we observed that LINC02820 only promoted the migration and invasion capabilities of ESCC cell lines. Mechanically, we found that LINC02820 may affect the cytoskeletal remodeling, interact with splice factor 3B subunit 3 (SF3B3), and cooperate with TNFα to amplify the NF-κB signaling pathway, which can lead to ESCC metastasis. Overall, our findings revealed that LINC02820 is a potential biomarker and therapeutic target for the diagnosis and treatment of ESCC.
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DOI：
10.1007/s00109-018-1621-1
发表时间：
2018-04
期刊：
Journal of molecular medicine (Berlin, Germany)
影响因子：
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DOI：
10.1158/1078-0432.ccr-16-2020
发表时间：
2017-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
Chen K;Xiao H;Zeng J;Yu G;Zhou H;Huang C;Yao W;Xiao W;Hu J;Guan W;Wu L;Huang J;Huang Q;Xu H;Ye Z
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Ye Z
影响因子：
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Zhang L
影响因子：
16.2
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Feng, Rui-Mei;Zong, Yi-Nan;Xu, Rui-Hua
通讯作者：
Xu, Rui-Hua
影响因子：
254.7
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