Molecular epidemiology of Methicillin-resistant Staphylococcus aureus in Africa: a systematic review.
Molecular epidemiology of Methicillin-resistant Staphylococcus aureus in Africa: a systematic review.
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DOI：
10.3389/fmicb.2015.00348
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发表时间：
2015
影响因子：
5.2
通讯作者：
Kaba M
中科院分区：
文献类型：
--
作者：
Abdulgader SM;Shittu AO;Nicol MP;Kaba M
耐甲氧西林金黄色葡萄球菌(MRSA)感染是一个严重的全球性问题，对患者的影响相当大，医疗费用也很高。本文系统综述了MRSA的克隆性多样性，以及潘顿-瓦伦丁杀白素(PVL)阳性MRSA在非洲的流行情况。两位作者使用预先定义的术语对非洲耐甲氧西林金黄色葡萄球菌的分子特征进行了搜索。我们从五个电子数据库中筛选了截至2014年10月以英语和法语发表的文章。总共确定了57项符合条件的研究。来自15个国家的34份报告提供了充分的基因分型数据。CC5是非洲医疗保健领域的主要克隆复合体。在9个非洲国家确定了与医院相关的MRSA ST239/ST241-III[3A]。该克隆在阿尔及利亚和尼日利亚也被描述为SCCmec IV[2B]型，在尼日尔被描述为V[5C]型。在非洲，欧洲ST80-IV[2B]克隆仅限于阿尔及利亚、埃及和突尼斯。克隆类型ST22-IV[2B]、ST36-II[2A]和ST612-IV[2B]仅在南非报道。在引起医院感染和社区感染的MRSA之间没有明显的区别。社区克隆ST8-IV[2B]和ST88-IV[2B]在安哥拉、喀麦隆、加蓬、加纳、马达加斯加、尼日利亚、S和普林西比的医院和社区中都有报告。在人类中，PVL阳性的MRSA携带和/或感染的比例从0.3%到100%不等。在非洲发现了一些大流行克隆人。此外，一些耐甲氧西林金黄色葡萄球菌克隆仅限于特定国家或地区。我们强烈主张在非洲开展更多关于MRSA的监测研究。
Methicillin-resistant Staphylococcus aureus (MRSA) infections are a serious global problem, with considerable impact on patients and substantial health care costs. This systematic review provides an overview on the clonal diversity of MRSA, as well as the prevalence of Panton-Valentine leukocidin (PVL)-positive MRSA in Africa. A search on the molecular characterization of MRSA in Africa was conducted by two authors using predefined terms. We screened for articles published in English and French through to October 2014 from five electronic databases. A total of 57 eligible studies were identified. Thirty-four reports from 15 countries provided adequate genotyping data. CC5 is the predominant clonal complex in the healthcare setting in Africa. The hospital-associated MRSA ST239/ST241-III [3A] was identified in nine African countries. This clone was also described with SCCmec type IV [2B] in Algeria and Nigeria, and type V [5C] in Niger. In Africa, the European ST80-IV [2B] clone was limited to Algeria, Egypt and Tunisia. The clonal types ST22-IV [2B], ST36-II [2A], and ST612-IV [2B] were only reported in South Africa. No clear distinctions were observed between MRSA responsible for hospital and community infections. The community clones ST8-IV [2B] and ST88-IV [2B] were reported both in the hospital and community settings in Angola, Cameroon, Gabon, Ghana, Madagascar, Nigeria, and São Tomé and Príncipe. The proportion of PVL-positive MRSA carriage and/or infections ranged from 0.3 to 100% in humans. A number of pandemic clones were identified in Africa. Moreover, some MRSA clones are limited to specific countries or regions. We strongly advocate for more surveillance studies on MRSA in Africa.
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DOI：
10.1007/s10096-010-1109-6
发表时间：
2011-04-01
影响因子：
4.5
作者：
Ben Slama, K.;Gharsa, H.;Torres, C.
通讯作者：
Torres, C.
影响因子：
3.7
作者：
Albrecht N;Jatzwauk L;Slickers P;Ehricht R;Monecke S
通讯作者：
Monecke S
DOI：
10.1093/jac/dkt418
发表时间：
2014-03
期刊：
The Journal of antimicrobial chemotherapy
影响因子：
--
作者：
Ba X;Harrison EM;Edwards GF;Holden MT;Larsen AR;Petersen A;Skov RL;Peacock SJ;Parkhill J;Paterson GK;Holmes MA
通讯作者：
Holmes MA
影响因子：
14.2
作者：
Antri, K.;Rouzic, N.;Etienne, J.
通讯作者：
Etienne, J.
影响因子：
2.6
作者：
Adesida, S;Boelens, H;Van Belkum, A
通讯作者：
Van Belkum, A