Directionality of Macrophages Movement in Tumour Invasion: A Multiscale Moving-Boundary Approach.
Directionality of Macrophages Movement in Tumour Invasion: A Multiscale Moving-Boundary Approach.
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DOI：
10.1007/s11538-020-00819-7
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发表时间：
2020-11-19
影响因子：
3.5
通讯作者：
Trucu D
中科院分区：
文献类型：
--
作者：
Suveges S;Eftimie R;Trucu D
浸润周围组织是公认的癌症特征之一（Hanahan and Weinberg in Cell 100: 57 - 70,2000）。10.1016/S0092-8674(00)81683-9)，这是通过复杂的异型多尺度动力学来完成的，包括癌细胞和其他伴随细胞（包括肿瘤相关巨噬细胞家族）群体在组织尺度上的随机和定向运动，以及基质降解酶的细胞尺度活性和细胞外基质（ECM）纤维细胞尺度成分的重排。所涉及的过程不仅包括细胞增殖和细胞粘附（与其他细胞和细胞外基质），还包括基质降解酶的分泌。这是癌细胞和巨噬细胞的结果，巨噬细胞是肿瘤微环境中最丰富的免疫细胞类型之一。在大肿瘤中，这些肿瘤相关巨噬细胞（tam）具有促进肿瘤的表型，有助于肿瘤的增殖和扩散。在本文中，我们扩展了先前的肿瘤侵袭的多尺度移动边界数学模型，同时考虑了tam的多尺度效应，特别关注它们的定向运动对肿瘤整体进展的影响。这个新模型的数值研究显示了促肿瘤tam和纤维ECM之间相互作用的重要性，突出了纤维对实体肿瘤空间结构的影响。
Invasion of the surrounding tissue is one of the recognised hallmarks of cancer (Hanahan and Weinberg in Cell 100: 57–70, 2000. 10.1016/S0092-8674(00)81683-9), which is accomplished through a complex heterotypic multiscale dynamics involving tissue-scale random and directed movement of the population of both cancer cells and other accompanying cells (including here, the family of tumour-associated macrophages) as well as the emerging cell-scale activity of both the matrix-degrading enzymes and the rearrangement of the cell-scale constituents of the extracellular matrix (ECM) fibres. The involved processes include not only the presence of cell proliferation and cell adhesion (to other cells and to the extracellular matrix), but also the secretion of matrix-degrading enzymes. This is as a result of cancer cells as well as macrophages, which are one of the most abundant types of immune cells in the tumour micro-environment. In large tumours, these tumour-associated macrophages (TAMs) have a tumour-promoting phenotype, contributing to tumour proliferation and spread. In this paper, we extend a previous multiscale moving-boundary mathematical model for cancer invasion, by considering also the multiscale effects of TAMs, with special focus on the influence that their directional movement exerts on the overall tumour progression. Numerical investigation of this new model shows the importance of the interactions between pro-tumour TAMs and the fibrous ECM, highlighting the impact of the fibres on the spatial structure of solid tumour.
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影响因子：
--
作者：
Chitu, Violeta;Yeung, Yee-Guide;Yu, Wenfeng;Nandi, Sayan;Stanley, E Richard
通讯作者：
Stanley, E Richard
影响因子：
2
作者：
Domschke, Pia;Trucu, Dumitru;Chaplain, Mark A. J.
通讯作者：
Chaplain, Mark A. J.
DOI：
10.1016/s0065-2377(08)00206-8
发表时间：
2009-01-01
期刊：
ENGINEERING ASPECTS OF SELF-ORGANIZING MATERIALS
影响因子：
--
作者：
Gras, Sally L.
通讯作者：
Gras, Sally L.
影响因子：
14
作者：
Gras, Sally L.;Tickler, Anna K.;MacPhee, Cait E.
通讯作者：
MacPhee, Cait E.
DOI：
10.1146/annurev-bioeng-071910-124729
发表时间：
2011-08-15
影响因子：
9.7
作者：
Deisboeck TS;Wang Z;Macklin P;Cristini V
通讯作者：
Cristini V