Successful Utilization of Levodopa in HIV-Induced Parkinsonism.

Successful Utilization of Levodopa in HIV-Induced Parkinsonism.
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DOI:
10.7759/cureus.11825
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发表时间:
2020-12-01
期刊:
Cureus
影响因子:
--
通讯作者:
Chand P
Chand P
中科院分区:
其他
文献类型:
--
作者:
Almajali M;Almajali F;Kafaie J;Chand P

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我们报告一例63岁的非洲裔美国女性患者,既往有人类免疫缺陷病毒(HIV)初治病史。她被转诊到我院,精神状态改变,僵硬,有进行性截肢困难的病史,据她儿子报告,在过去的几个月里语言输出减少。她的临床表现和脑MRI与HIV脑病伴双侧基底节受累和HIV诱导的帕金森综合征一致。我们启动了一项卡比多巴/左旋多巴沿着高效抗逆转录病毒治疗(HAART)(恩曲他滨-替诺福韦和度鲁特韦)的试验。在接下来的三周里,她在临床和放射学上都表现出了巨大的改善。她对卡比多巴/左旋多巴耐受良好,没有行为或神经副作用。该病例说明了卡比多巴/左旋多巴在治疗患有HIV脑病的成年女性患者的帕金森综合征中的安全使用。
We report a case of a 63-year-old African American female patient with a past medical history of treatment naïve human immunodeficiency virus (HIV). She was referred to our hospital with altered mental status and rigidity with a history of progressive ambulation difficulties and decreased verbal output over the previous months as reported by her son. Her clinical presentation and brain MRI were consistent with HIV encephalopathy with bilateral basal ganglia involvement and HIV-induced parkinsonism. We initiated a trial of carbidopa/levodopa along with highly active antiretroviral therapy (HAART) (emtricitabine-tenofovir and dolutegravir). In the following three weeks, she demonstrated dramatic improvement, both clinically and radiologically. She tolerated carbidopa/levodopa well with no behavioral or neurological side effects. This case illustrates the safe utilization of carbidopa/levodopa in treating parkinsonism in an adult female patient with HIV encephalopathy.
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