Neuromuscular stimulation therapy after incomplete spinal cord injury promotes recovery of interlimb coordination during locomotion.
Neuromuscular stimulation therapy after incomplete spinal cord injury promotes recovery of interlimb coordination during locomotion.
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DOI：
10.1088/1741-2560/6/5/055010
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发表时间：
2009-10
影响因子：
4
通讯作者：
Abbas JJ
中科院分区：
文献类型：
--
作者：
Jung R;Belanger A;Kanchiku T;Fairchild M;Abbas JJ
不完全脊髓损伤（iSCI）后神经肌肉电刺激（NMES）诱导重复肢体运动治疗的影响机制尚不清楚。本研究确立了在患有 iSCI 的啮齿类动物中使用治疗性 NMES 的能力，并评估了其促进运动期间肢体间控制恢复的能力。 10 只成年雌性 Long Evans 大鼠遭受胸椎挫伤（T9；156 ± 9.52 Kdyne）。恢复后 7 天，6/10 只动物通过两侧植入髋屈肌和伸肌的电极接受 NMES 治疗，每天 15 分钟，持续 5 天。六只完整的动物作为对照。使用 BBB 运动量表评估受伤后前 6 天和第 14 天的运动功能。受伤后第 14 天对跑步机行走进行 3D 运动学分析。接受 NMES 治疗的啮齿类动物在控制髋关节方面表现出肢体间协调性的改善，髋关节是 NMES 的具体目标。治疗组的对称指数显着改善。此外，接受治疗的受伤啮齿动物更一致地表现出高比例的 1:1 协调步态，并且更一致地实现了正确的后肢触地时机。这些结果表明 NMES 技术可以为 iSCI 后的神经运动治疗提供有效的治疗工具。
The mechanisms underlying the effects of neuromuscular electrical stimulation (NMES) induced repetitive limb movement therapy after incomplete spinal cord injury (iSCI) are unknown. This study establishes the capability of using therapeutic NMES in rodents with iSCI and evaluates its ability to promote recovery of interlimb control during locomotion. Ten adult female Long Evans rats received thoracic spinal contusion injuries (T9; 156 ± 9.52 Kdyne). 7 days post-recovery, 6/10 animals received NMES therapy for 15 min/day for 5 days, via electrodes implanted bilaterally into hip flexors and extensors. Six intact animals served as controls. Motor function was evaluated using the BBB locomotor scale for the first 6 days and on 14th day post-injury. 3D kinematic analysis of treadmill walking was performed on day 14 post-injury. Rodents receiving NMES therapy exhibited improved interlimb coordination in control of the hip joint, which was the specific NMES target. Symmetry indices improved significantly in the therapy group. Additionally, injured rodents receiving therapy more consistently displayed a high percentage of 1:1 coordinated steps, and more consistently achieved proper hindlimb touchdown timing. These results suggest that NMES techniques could provide an effective therapeutic tool for neuromotor treatment following iSCI.
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影响因子：
3
作者：
Ichihara, Kazuhiko;Venkatasubramanian, Ganapriya;Abbas, James J.;Jung, Ranu
通讯作者：
Jung, Ranu
DOI：
10.1109/tbme.2008.2008193
发表时间：
2009-02
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Kim SJ;Fairchild MD;Iarkov Yarkov A;Abbas JJ;Jung R
通讯作者：
Jung R
影响因子：
14.5
作者：
Hutchinson, KJ;Gómez-Pinilla, F;Basso, DM
通讯作者：
Basso, DM
影响因子：
2.5
作者：
Hiebert, GW;Whelan, PJ;Pearson, KG
通讯作者：
Pearson, KG
影响因子：
--
作者：
Edgerton, V. Reggie;Courtine, Gregoire;Roy, Roland R.
通讯作者：
Roy, Roland R.