Parsing dimensional vs diagnostic category-related patterns of reward circuitry function in behaviorally and emotionally dysregulated youth in the Longitudinal Assessment of Manic Symptoms study.
Parsing dimensional vs diagnostic category-related patterns of reward circuitry function in behaviorally and emotionally dysregulated youth in the Longitudinal Assessment of Manic Symptoms study.
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DOI：
10.1001/jamapsychiatry.2013.2870
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发表时间：
2014-01
期刊：
影响因子：
25.8
通讯作者：
Phillips, Mary L.
中科院分区：
文献类型：
--
作者：
Bebko, Genna;Bertocci, Michele A.;Fournier, Jay C.;Hinze, Amanda K.;Bonar, Lisa;Almeida, Jorge R. C.;Perlman, Susan B.;Versace, Amelia;Schirda, Claudiu;Travis, Michael;Gill, Mary Kay;Demeter, Christine;Diwadkar, Vaibhav A.;Ciuffetelli, Gary;Rodriguez, Eric;Olino, Thomas;Forbes, Erika;Sunshine, Jeffrey L.;Holland, Scott K.;Kowatch, Robert A.;Birmaher, Boris;Axelson, David;Horwitz, Sarah M.;Arnold, L. Eugene;Fristad, Mary A.;Youngstrom, Eric A.;Findling, Robert L.;Phillips, Mary L.
Pediatric disorders characterized by behavioral and emotional dysregulation pose diagnostic and treatment challenges because of high comorbidity, suggesting that they may be better conceptualized dimensionally rather than categorically. Identifying neuroimaging measures associated with behavioral and emotional dysregulation in youth may inform understanding of underlying dimensional vs. disorder-specific pathophysiology. Identify, in a large cohort of behaviorally and emotionally dysregulated youth, neuroimaging measures that: 1) are associated with behavioral and emotional dysregulation pathological dimensions (behavioral and emotional dysregulation measured with the Parent General Behavior Inventory 10 Item Mania Scale [PGBI-10M], mania, depression, anxiety); or 2) differentiate diagnostic categories(BPSD, ADHD, anxiety, disruptive behavior disorders (DBD)). Multi-site neuroimaging study(February 2011–April 2012). Academic medical centers: Case Western Reserve University, Cincinnati Children’s Hospital, University of Pittsburgh. Referred sample of behaviorally and emotionally dysregulated youth(n=85) from the Longitudinal Assessment of Manic Symptoms study and healthy youth (n=20). Region-of-interest analyses examined relationships among prefrontal-ventral striatal reward circuitry during a reward paradigm (Win, Loss, control conditions), symptom dimensions, and diagnostic categories. Regardless of diagnosis, higher PGBI-10M scores were associated with greater left middle prefrontal cortical (mPFC; r=0.28), and greater levels of anxiety with greater right dorsal anterior cingulate cortical (dACC; r=0.27), activity to Win. The 20 highest (t=2.75) and 20 lowest (t=2.42) PGBI-10M scoring youth showed significantly greater left mPFC activity to Win than 20 healthy youth. DBD were associated with lower left ventrolateral prefrontal cortex(VLPFC) activity to Win (t=2.68) (all ps<0.05, corrected). Greater PGBI-10M-related left mPFC activity, and greater anxiety-related right dACC activity, to Win may reflect heightened reward sensitivity and greater attention to reward in behaviorally and emotionally dysregulated youth, regardless of diagnosis. Reduced left VLPFC activity to Win may reflect reward insensitivity in youth with DBD. Despite a distinct reward-related neurophysiology in DBD, findings generally support a dimensional approach to studying neural mechanisms in behaviorally and emotionally dysregulated youth.
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影响因子：
5.7
作者：
Eklund, Anders;Andersson, Mats;Knutsson, Hans
通讯作者：
Knutsson, Hans
DOI：
10.1097/00004583-199201000-00016
发表时间：
1992-01-01
影响因子：
13.3
作者：
HIRSHFELD, DR;ROSENBAUM, JF;KAGAN, J
通讯作者：
KAGAN, J
DOI：
10.1097/00004583-199704000-00018
发表时间：
1997-04-01
影响因子：
13.3
作者：
Birmaher, B;Khetarpal, S;Neer, SM
通讯作者：
Neer, SM
DOI：
10.1176/appi.ajp.2008.07081336
发表时间：
2009-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Forbes EE;Hariri AR;Martin SL;Silk JS;Moyles DL;Fisher PM;Brown SM;Ryan ND;Birmaher B;Axelson DA;Dahl RE
通讯作者：
Dahl RE
DOI：
10.1176/appi.ajp.2012.12020169
发表时间：
2013-05
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Caseras X;Lawrence NS;Murphy K;Wise RG;Phillips ML
通讯作者：
Phillips ML