Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice.
Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice.
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DOI：
10.1038/nnano.2016.23
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发表时间：
2016-07
影响因子：
38.3
通讯作者：
Liang XJ
中科院分区：
文献类型：
--
作者：
Xue X;Yang JY;He Y;Wang LR;Liu P;Yu LS;Bi GH;Zhu MM;Liu YY;Xiang RW;Yang XT;Fan XY;Wang XM;Qi J;Zhang HJ;Wei T;Cui W;Ge GL;Xi ZX;Wu CF;Liang XJ
甲基苯丙胺(冰毒)滥用是世界范围内一个严重的社会和健康问题。目前，还没有有效的药物来治疗冰毒成瘾。在这里，我们报告了聚集的单壁碳纳米管(ASWNTs)显著抑制了冰毒自我给药、冰毒诱导的条件性位置偏爱和冰毒或线索诱导的小鼠对药物寻找行为的复发。单独使用aSWNTs并没有显著改变中脑边缘多巴胺系统，而用aSWNTs预处理可减弱冰毒诱导的腹侧纹状体细胞外多巴胺的增加。电化学测试表明，aSWNTs促进了多巴胺的氧化。此外，aSWNTs可减弱冰毒诱导的酪氨酸羟基酶或突触蛋白表达的增加。这些发现表明，aSWNTs可能通过氧化甲基增强的纹状体细胞外多巴胺来治疗冰毒成瘾。
Methamphetamine (METH) abuse is a serious social and health problem worldwide. At present, there are no effective medications to treat METH addiction. Here, we report that aggregated single-walled carbon nanotubes (aSWNTs) significantly inhibited METH self-administration, METH-induced conditioned place preference and METH- or cue-induced relapse to drug-seeking behaviour in mice. The use of aSWNTs alone did not significantly alter the mesolimbic dopamine system, whereas pretreatment with aSWNTs attenuated METH-induced increases in extracellular dopamine in the ventral striatum. Electrochemical assays suggest that aSWNTs facilitated dopamine oxidation. In addition, aSWNTs attenuated METH-induced increases in tyrosine hydroxylase or synaptic protein expression. These findings suggest that aSWNTs may have therapeutic effects for treatment of METH addiction by oxidation of METH-enhanced extracellular dopamine in the striatum.
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影响因子：
38.3
作者：
通讯作者：
--
影响因子：
3.7
作者：
Wise, Roy A.
通讯作者：
Wise, Roy A.
影响因子：
17.1
作者：
Ma, Xiaowei;Zhang, Li-Hua;Wang, Li-Rong;Xue, Xue;Sun, Ji-Hong;Wu, Yan;Zou, Guozhang;Wu, Xia;Wang, Paul C.;Wamer, Wayne G.;Yin, Jun-Jie;Zheng, Kaiyuan;Liang, Xing-Jie
通讯作者：
Liang, Xing-Jie
影响因子：
3.1
作者：
Edwards, Sharon L.;Werkmeister, Jerome A.;Ramshaw, John A. M.
通讯作者：
Ramshaw, John A. M.
渴望孵化的神经生物学。
影响因子：
15.9
作者：
Pickens, Charles L.;Airavaara, Mikko;Theberge, Florence;Fanous, Sanya;Hope, Bruce T.;Shaham, Yavin
通讯作者：
Shaham, Yavin