Gut Microbiome and Bone: to Build, Destroy, or Both?
Gut Microbiome and Bone: to Build, Destroy, or Both?
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DOI：
10.1007/s11914-017-0382-z
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发表时间：
2017-08
影响因子：
4.3
通讯作者：
Charles JF
中科院分区：
文献类型：
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作者：
Yan J;Charles JF
The gut microbiota can be considered a hidden organ that plays essential roles in host homeostasis. Exploration of the effects of microbiota on bone have just begun. Complimentary studies using germ-free mice, antibiotic and probiotic treatments reveal a complicated relationship between microbiota and bone. Here we review recent reports addressing the effect of gut microbiota on bone health, discuss potential reasons for discrepant findings, and explore potential mechanisms for these effects. Manipulation of microbiota by colonization of germ free mice, antibiotics or probiotic supplementation significantly alters bone remodeling, bone development and growth, as well as bone mechanical strength. Different experimental models reveal context dependent effects of gut microbiota on bone. By examining phenotypic effects, experimental context and proposed mechanisms, revealed by recent reports, we hope to provide comprehensive and fresh insights into the many facets of microbiota and bone interactions.
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