Histological and immunological characteristics of the junctional epithelium.

Histological and immunological characteristics of the junctional epithelium.
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DOI:
10.1016/j.jdsr.2017.11.004
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发表时间:
2018-05
期刊:
The Japanese dental science review
影响因子:
--
通讯作者:
Nakamura M
Nakamura M
中科院分区:
其他
文献类型:
--
作者:
Nakamura M

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上皮组织的连续性因牙齿萌出而瓦解。交界上皮(JE)通过半桥粒附着在牙齿表面,构成对抗牙周细菌感染的前线防御。乙脑持续表达细胞间粘附分子-1 (ICAM-1),中性粒细胞和淋巴细胞通过这些迁移细胞表面表达的 ICAM-1 和 LFA-1 之间的相互作用渗透到乙脑中。日本脑炎还表达细胞因子和趋化因子。即使在无菌条件下,乙脑的这些功能也能保持。因此,粘附分子、细胞因子和趋化因子的组成型表达不仅可以用于抗病原体防御,还可以用于维持乙脑的生理稳态。在这篇综述中,我们主要关注乙脑的结构和功能特征,并讨论了乙脑中上皮内淋巴细胞作为前线抗菌防御屏障和乙脑止血调节剂的功能。
The continuity of epithelial tissue is collapsed by tooth eruption. The junctional epithelium (JE) is attached to the tooth surface by hemidesmosomes, which constitutes the front-line defense against periodontal bacterial infection. JE constitutively expresses intercellular adhesion molecule-1 (ICAM-1), and neutrophils and lymphocytes penetrate into JE via interaction between ICAM-1 and LFA-1 expressed on the surface of these migrating cells. JE also expresses cytokines and chemokines. These functions of JE are maintained even in germ-free condition. Therefore, the constitutive expression of adhesion molecules, cytokines, and chemokines might be used not only for anti-pathogenic defense but also for maintaining the physiological homeostasis of JE. In this review, we have mainly focused on the structural and functional features of JE, and discussed the function of intraepithelial lymphocytes in JE as a front-line anti-microbial defense barrier and regulator of JE hemostasis.
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