Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma.
Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma.
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DOI：
10.1038/sj.bjc.6600696
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发表时间：
2003-01-13
影响因子：
8.8
通讯作者：
Scherübl, H
中科院分区：
文献类型：
--
作者：
Grabowski, P;Kühnel, T;Mühr-Wilkenshoff, F;Heine, B;Stein, H;Höpfner, M;Germer, CT;Scherübl, H
关键词：
Survivin是凋亡抑制因子家族的新成员，几乎只在增殖细胞中表达，尤其是在癌症中。Survivin蛋白在食道鳞状细胞癌中的亚细胞定位和预后意义尚未确定。84例食管鳞癌患者的生存期与肿瘤细胞核中Survivin的免疫组织化学表达程度有关。当>；5%的细胞染色阳性时，肿瘤评分为阳性。对患者进行至少5年的随访，直至死亡。在正常食管鳞状细胞上皮中，Survivin在基底层细胞中有少量胞浆表达，而在增殖细胞中可见Survivin蛋白的胞核表达。67例(80%)癌组织中有Survivin的核表达。本组患者的平均生存期(28个月，20~36个月)显著低于肿瘤细胞核内无Survivin表达的患者(108个月，62~154个月，P=0.003)。单因素分析显示，Survivin核表达(P=0.003)、肿瘤深度(P=0.001)、淋巴结转移(P=0.003)和分期(P<；0.001)是影响预后的最佳因素。相反，53例(63%)肿瘤胞浆Survivin染色阳性，与预后无关。总之，对Survivin核表达的分析确定了食管鳞癌中预后良好(Survivin−)或预后不良(Survivin+)的亚型。我们建议，Survivin核表达的测定可以用于未来对食管鳞癌的个体化治疗策略。
Survivin, a new member of the family of apoptosis inhibitors, is expressed almost exclusively in proliferating cells, above all in cancers. Subcellular localisation and prognostic implications of the survivin protein have not yet been determined in oesophageal squamous cell carcinoma. The survival of 84 patients with oesophageal squamous cell carcinomas was correlated with the extent of immunohistochemical survivin expression in tumour cell nuclei. Tumours were scored positive when >5% cells stained positive. Patients were followed up for at least 5 years or until death. In normal oesophageal squamous cell epithelium, some cytoplasmic survivin expression was detected in the basal cells, whereas proliferating cells showed nuclear staining of survivin. Nuclear expression of survivin was also detected in 67 cancers (80%). The mean survival for patients of this group (28 months, range 20–36) was significantly less than that for patients without survivin expression in the tumour cell nuclei (108 months, range 62–154, P=0.003). Using univariate analysis, nuclear survivin expression (P=0.003), tumour depth (P=0.001), lymph node metastasis (P=0.003) and stage (P<0.001) were the best predictors of survival. In contrast, cytoplasmic survivin staining was noted in 53 (63%) tumours and had no prognostic relevance. In conclusion, the analysis of nuclear survivin expression identifies subgroups in oesophageal squamous cell cancer with favourable (survivin−) or with poor prognosis (survivin+). We suggest that the determination of nuclear survivin expression could be used to individualise therapeutic strategies in oesophageal squamous cell cancer in the future.
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