Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment.
Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment.
复制标题
DOI：
10.1037/a0036299
复制
发表时间：
2014-05
影响因子：
4.6
通讯作者：
Schoen N
中科院分区：
文献类型：
--
作者：
Barch DM;Treadway MT;Schoen N
精神分裂症最令人衰弱的方面之一是对奖励的明显兴趣或努力努力的能力。这种“阴性症状”可能会阻止个人在教育、职业或社会领域获得潜在的有益结果。在动物模型中，多巴胺异常会降低为奖励而工作的意愿，这表明 DA 功能是阴性症状的候选底物，因为精神分裂症涉及多巴胺系统的失调。我们使用奖励的努力支出任务（EEfRT）来评估精神分裂症患者愿意为更大的奖励或更有可能的奖励付出更多努力的程度。 59 名精神分裂症患者和 39 名人口统计相似的对照组执行了 EEfRT 任务，其中包括在“简单”和“困难”任务之间做出选择，以获得潜在的奖励。随着奖励幅度或概率的增加，精神分裂症患者的努力分配增幅较小。在对照组中，在高奖励幅度和概率条件下选择困难任务的频率与抑郁严重程度和快感缺失呈负相关。在精神分裂症中，根据看护者的评估，较少的艰巨任务选择与更严重的阴性症状以及更差的社区和工作功能相关。与在精神分裂症动物模型中观察到的多巴胺功能紊乱的模式一致，这些结果表明，导致精神分裂症功能和动机受损的一种机制可能是减少对更高强度或更高概率奖励的更大努力的分配。
One of the most debilitating aspects of schizophrenia is an apparent of interest in or ability to exert effort for rewards. Such “negative symptoms” may prevent individuals from obtaining potentially beneficial outcomes in educational, occupational or social domains. In animal models, dopamine abnormalities decrease willingness to work for rewards, implicating DA function as a candidate substrate for negative symptoms given that schizophrenia involves dysregulation of the dopamine system. We used the Effort-Expenditure for Rewards Task (EEfRT) to assess the degree to which individuals with schizophrenia were wiling to exert increased effort for either larger magnitude rewards or for rewards that were more probable. Fifty-nine individuals with schizophrenia and thirty-nine demographically similar controls performed the EEfRT task, which involves making choices between “easy” and “hard” tasks to earn potential rewards. Individuals with schizophrenia showed less of an increase in effort allocation as either reward magnitude or probability increased. In controls, the frequency of choosing the hard task in high reward magnitude and probability conditions was negatively correlated with depression severity and anhedonia. In schizophrenia, fewer hard task choices were associated with more severe negative symptoms and worse community and work function as assessed by a caretaker. Consistent with patterns of disrupted dopamine functioning observed in animal models of schizophrenia, these results suggest that one mechanism contributing to impaired function and motivational drive in schizophrenia may be a reduced allocation of greater effort for higher magnitude or higher probability rewards.
登录
查看更多内容
影响因子：
11.3
作者：
Brown JK;Waltz JA;Strauss GP;McMahon RP;Frank MJ;Gold JM
通讯作者：
Gold JM
影响因子：
6.6
作者：
Fusar-Poli, Paolo;Meyer-Lindenberg, Andreas
通讯作者：
Meyer-Lindenberg, Andreas
影响因子：
3.3
作者：
Gard, David E.;Gard, Marja Germans;John, Oliver P.
通讯作者：
John, Oliver P.
DOI：
10.1073/pnas.97.14.8104
发表时间：
2000-07-05
影响因子：
11.1
作者：
Abi-Dargham, A;Rodenhiser, J;Laruelle, M
通讯作者：
Laruelle, M
影响因子：
4.8
作者：
Fervaha, Gagan;Graff-Guerrero, Ariel;Remington, Gary
通讯作者：
Remington, Gary