The Dynamic Regulation of mRNA Translation and Ribosome Biogenesis During Germ Cell Development and Reproductive Aging.
The Dynamic Regulation of mRNA Translation and Ribosome Biogenesis During Germ Cell Development and Reproductive Aging.
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DOI：
10.3389/fcell.2021.710186
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发表时间：
2021
影响因子：
5.5
通讯作者：
Buszczak M
中科院分区：
文献类型：
--
作者：
Mercer M;Jang S;Ni C;Buszczak M
无论是在全球范围内还是在单个转录本的水平上，mRNA翻译的调控在不同物种的生殖细胞的发育和功能中都发挥着核心作用。利用苍蝇、蠕虫、斑马鱼和老鼠进行的遗传学研究强调了特定的RNA结合蛋白在驱动生殖细胞形成和功能的各个方面的重要性。其中许多mRNA结合蛋白，包括Pumilio、Nanos、Vasa和DAZL，在进化过程中被保守，专门标记生殖细胞，并在不同物种之间执行类似的功能。这些蛋白质通常通过与靶信息的3‘非翻译区(UTR)内的特定元件结合来影响mRNA的翻译。越来越多的证据表明，mRNA翻译的全球调控在生殖细胞发育中也起着重要作用。例如，核糖体的生物发生通常在配子发生过程中以阶段特异性的方式调节。此外，卵母细胞需要产生和储存足够数量的核糖体来支持早期胚胎的发育，直到合子转录的启动。越来越多的证据表明，mRNA翻译调控机制的破坏可能导致人类不孕不育和生殖衰老。这些发现强调了进一步深入了解生殖细胞内控制信使核糖核酸翻译的机制的重要性。未来在这一领域的工作可能会产生超出生殖细胞生物学的重要影响。
The regulation of mRNA translation, both globally and at the level of individual transcripts, plays a central role in the development and function of germ cells across species. Genetic studies using flies, worms, zebrafish and mice have highlighted the importance of specific RNA binding proteins in driving various aspects of germ cell formation and function. Many of these mRNA binding proteins, including Pumilio, Nanos, Vasa and Dazl have been conserved through evolution, specifically mark germ cells, and carry out similar functions across species. These proteins typically influence mRNA translation by binding to specific elements within the 3′ untranslated region (UTR) of target messages. Emerging evidence indicates that the global regulation of mRNA translation also plays an important role in germ cell development. For example, ribosome biogenesis is often regulated in a stage specific manner during gametogenesis. Moreover, oocytes need to produce and store a sufficient number of ribosomes to support the development of the early embryo until the initiation of zygotic transcription. Accumulating evidence indicates that disruption of mRNA translation regulatory mechanisms likely contributes to infertility and reproductive aging in humans. These findings highlight the importance of gaining further insights into the mechanisms that control mRNA translation within germ cells. Future work in this area will likely have important impacts beyond germ cell biology.
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影响因子：
64.5
作者：
Buszczak M;Signer RA;Morrison SJ
通讯作者：
Morrison SJ
影响因子：
11.8
作者：
Carreira-Rosario A;Bhargava V;Hillebrand J;Kollipara RK;Ramaswami M;Buszczak M
通讯作者：
Buszczak M
影响因子：
56.9
作者：
BROWN, DD;DAWID, IB
通讯作者：
DAWID, IB
影响因子：
10.5
作者：
Breitwieser, W;Markussen, FH;Ephrussi, A
通讯作者：
Ephrussi, A
影响因子：
2.7
作者：
BACHVAROVA, R;DELEON, V
通讯作者：
DELEON, V