Guided bone regeneration: materials and biological mechanisms revisited.
Guided bone regeneration: materials and biological mechanisms revisited.
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DOI：
10.1111/eos.12364
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发表时间：
2017-10
影响因子：
1.9
通讯作者：
Thomsen P
中科院分区：
文献类型：
--
作者：
Elgali I;Omar O;Dahlin C;Thomsen P
引导骨再生（GBR）通常与钛植入物的安装结合使用。应用膜排除非成骨组织干扰骨再生是GBR的关键原则。膜材料具有许多可以改性的性质。已经引入了大量的膜用于实验和临床验证。这提示需要更新膜的性能和生物学结果，以及对膜覆盖的缺损中骨再生的生物学机制进行严格评估。在MEDLINE/PubMed数据库检索后，对本叙述性综述的相关文献进行了评估。实验数据表明，膜的物理化学和机械性能的不同修饰可以促进骨再生。然而，膜孔隙率的GBR膜的屏障功能的确切作用仍有待阐明。新的实验结果还表明，在GBR期间，膜隔室本身在促进潜在缺陷的再生过程中发挥积极作用，而不是纯粹的被动屏障。通过系统地解决屏障和生物活性特性来优化膜材料是该研究领域的重要策略。
Guided bone regeneration (GBR) is commonly used in combination with the installment of titanium implants. The application of a membrane to exclude non‐osteogenic tissues from interfering with bone regeneration is a key principle of GBR. Membrane materials possess a number of properties which are amenable to modification. A large number of membranes have been introduced for experimental and clinical verification. This prompts the need for an update on membrane properties and the biological outcomes, as well as a critical assessment of the biological mechanisms governing bone regeneration in defects covered by membranes. The relevant literature for this narrative review was assessed after a MEDLINE/PubMed database search. Experimental data suggest that different modifications of the physicochemical and mechanical properties of membranes may promote bone regeneration. Nevertheless, the precise role of membrane porosities for the barrier function of GBR membranes still awaits elucidation. Novel experimental findings also suggest an active role of the membrane compartment per se in promoting the regenerative processes in the underlying defect during GBR, instead of being purely a passive barrier. The optimization of membrane materials by systematically addressing both the barrier and the bioactive properties is an important strategy in this field of research.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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DOI：
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发表时间：
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影响因子：
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