Conditioned place preference induced by social play behavior: parametrics, extinction, reinstatement and disruption by methylphenidate.
Conditioned place preference induced by social play behavior: parametrics, extinction, reinstatement and disruption by methylphenidate.
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DOI：
10.1016/j.euroneuro.2009.03.006
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发表时间：
2009-09
影响因子：
5.6
通讯作者：
Vanderschuren, Louk J. M. J.
中科院分区：
文献类型：
--
作者：
Trezza, Viviana;Damsteegt, Ruth;Vanderschuren, Louk J. M. J.
在这项研究中，我们研究了青春期大鼠社交互动引起的条件性位置偏好（CPP）的行为因素。我们发现，社会诱发的 CPP 的程度取决于动物的社会动机和训练量。灭绝后，社会诱发的 CPP 可以通过一次修复恢复。哌醋甲酯治疗会扰乱青春期大鼠的社交游戏行为，但不会扰乱社交探索行为，从而阻止了社交诱发的 CPP 的发展。有趣的是，哌醋甲酯本身可诱导 CPP。这些数据表明： 1. 社交互动对青春期大鼠来说是有益的； 2. 食欲和记忆因素影响社会性CPP的发展； 3. 与药物引起的CPP相比，社会引起的CPP可以被消灭和恢复； 4. 社交游戏可能是青春期大鼠社交互动中最有价值的方面； 5. 社会背景影响哌醋甲酯的主观效果。
In this study, we investigated behavioral factors underlying conditioned place preference (CPP) induced by social interaction in adolescent rats. We found that the magnitude of socially-induced CPP depended on the social motivation of the animals and on the amount of training. After extinction, socially-induced CPP could be reinstated by a single reconditioning session. Treatment with methylphenidate, which disrupts social play behavior in adolescent rats, but not social exploratory behavior, prevented the development of socially-induced CPP. Interestingly, methylphenidate by itself induced CPP. These data demonstrate that: 1. social interaction is rewarding in adolescent rats; 2. appetitive and mnemonic factors influence the development of socially-induced CPP; 3. comparable to drug-induced CPP, socially-induced CPP can be extinguished and reinstated; 4. social play is likely to be the most rewarding aspect of social interaction in adolescent rats; 5. social context influences the subjective effects of methylphenidate.
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影响因子：
2.7
作者：
Panksepp, J;Burgdorf, J
通讯作者：
Burgdorf, J
影响因子：
3.4
作者：
Keiflin, Ronald;Isingrini, Elsa;Cador, Martine
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Cador, Martine
影响因子：
2.5
作者：
HUMPHREYS, AP;EINON, DF
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2.2
作者：
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PANKSEPP, J
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2.2
作者：
Douglas, LA;Varlinskaya, EI;Spear, LP
通讯作者：
Spear, LP