In vitro anti-osteoporosis properties of diverse Korean Drynariae rhizoma phenolic extracts.
In vitro anti-osteoporosis properties of diverse Korean Drynariae rhizoma phenolic extracts.
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DOI：
10.3390/nu6041737
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发表时间：
2014-04-24
期刊：
影响因子：
5.9
通讯作者：
Kim IS
中科院分区：
文献类型：
--
作者：
Kang SN;Lee JS;Park JH;Cho JH;Park JH;Cho KK;Lee OH;Kim IS
骨碎补已被用于防止随着年龄的增长而发生的骨质流失。然而，对草药中作用于骨代谢的提取物中的化学化合物知之甚少。研究并比较石斛水提物（DR-DW）和醇提物（DR-EtOH）的多酚类化合物提取效果、抗氧化活性及体外抗骨质疏松作用。根茎。70%乙醇提取总酚和总黄酮的效果较好，该方法提取的总酚和总黄酮具有较高的抗氧化活性和体外抗骨质疏松作用。特别是，DR-EtOH中间苯三酚、原儿茶酸乙酯、2-氨基-3，4-二甲基-苯甲酸、3-（3，5-二甲基-吡唑-1-基）-苯甲酸、绿原酸、胡萝卜酸、反式阿魏酸、（-）-表没食子儿茶素、表没食子儿茶素没食子酸酯、槲皮素、木犀草素和大黄素的含量高于DR-DW中的含量。这些结果表明，DR-EtOH可以是一个很好的天然草药来源，具有抗骨质疏松症的性质。
Drynariae rhizoma has been used to prevent bone loss that occurs with increasing age. However, the chemical compounds in extracts that act on bone metabolism in herbal medicine are poorly understood. This study aimed to investigate and compare the extraction efficacy of polyphenolic compounds, antioxidant activity, and in vitro anti-osteoporosis properties of water extract (DR-DW) and ethanol extract (DR-EtOH) from D. rhizoma. Total phenolics and flavonoids were better extracted with 70% EtOH, and this extraction method also resulted in higher antioxidant activity and in vitro anti-osteoporosis properties in these extracts. In particular, the contents of phloroglucinol, protocatechuic acid ethyl ester, 2-amino-3,4-dimethyl-benzoic acid, 3-(3,5-dimethyl-pyrazol-1-yl)-benzoic acid, chlorogenic acid, syringic acid, trans-ferulic acid, (−)-epigallocatechin, epigallocatechin gallate, quercetin dehydrate, luteolin and emodin in DR-EtOH were higher than those in DR-DW. These results indicated that DR-EtOH could be a good source of natural herbs with anti-osteoporosis properties.
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DOI：
10.3390/molecules15107313
发表时间：
2010-10-21
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Dai J;Mumper RJ
通讯作者：
Mumper RJ
影响因子：
9.3
作者：
Jeong, JC;Lee, BT;Kim, CH
通讯作者：
Kim, CH
影响因子：
39.2
作者：
ETTINGER, B;GENANT, HK;CANN, CE
通讯作者：
CANN, CE
影响因子：
5.4
作者：
Liu, Xinyu;Zhang, Shangshang;Xiong, Zhili
通讯作者：
Xiong, Zhili
影响因子：
4.9
作者：
HOVIK, P;SUNDSBAK, HP;SANDVIK, L
通讯作者：
SANDVIK, L