The Evolution of Sox Gene Repertoires and Regulation of Segmentation in Arachnids.
The Evolution of Sox Gene Repertoires and Regulation of Segmentation in Arachnids.
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蛛形纲动物Sox基因库的进化与分节调控。
DOI：
10.1093/molbev/msab088
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发表时间：
2021-07-29
影响因子：
10.7
通讯作者：
McGregor AP
中科院分区：
文献类型：
--
作者：
Baudouin-Gonzalez L;Schoenauer A;Harper A;Blakeley G;Seiter M;Arif S;Sumner-Rooney L;Russell S;Sharma PP;McGregor AP
Sox家族的转录因子调节后生动物发育过程中的许多过程，包括干细胞的维持和神经系统的规范。因此，表征这些基因的功能和作用可以为动物进化和发育提供重要的见解。我们进一步的特点是Sox剧目的几个蛛形纲动物物种与祖先的全基因组重复，并比较它们之间的蜘蛛寄生虫tepidariorum和收割者Phalangium opilio的表达。我们发现大多数Sox家族在全基因组复制和潜在的亚功能化和/或新功能化事件的证据后被保留为ohnologs。我们的研究结果还表明，Sox 21 b-1可能在蛛形纲动物的祖先调节分割，在昆虫中发挥类似的作用，密切相关的SoxB基因，Dichaete。我们以前的研究表明，Sox 21 b-1是必需的同时形成的前体片段和顺序添加后体节在P. tepidariorum。我们进一步研究了Sox 21 b-1在该蜘蛛中的表达和功能，发现尽管该基因调节前体和后体节段的产生，但它在这些tagmata的形成中起着不同的作用，反映了不同结构的基因调控网络的分割和部署模式。
The Sox family of transcription factors regulates many processes during metazoan development, including stem cell maintenance and nervous system specification. Characterizing the repertoires and roles of these genes can therefore provide important insights into animal evolution and development. We further characterized the Sox repertoires of several arachnid species with and without an ancestral whole-genome duplication and compared their expression between the spider Parasteatoda tepidariorum and the harvestman Phalangium opilio. We found that most Sox families have been retained as ohnologs after whole-genome duplication and evidence for potential subfunctionalization and/or neofunctionalization events. Our results also suggest that Sox21b-1 likely regulated segmentation ancestrally in arachnids, playing a similar role to the closely related SoxB gene, Dichaete, in insects. We previously showed that Sox21b-1 is required for the simultaneous formation of prosomal segments and sequential addition of opisthosomal segments in P. tepidariorum. We studied the expression and function of Sox21b-1 further in this spider and found that although this gene regulates the generation of both prosomal and opisthosomal segments, it plays different roles in the formation of these tagmata reflecting their contrasting modes of segmentation and deployment of gene regulatory networks with different architectures.
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