Effects of baroreceptor activation on respiratory variability in rat.
Effects of baroreceptor activation on respiratory variability in rat.
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DOI：
10.1016/j.resp.2009.02.006
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发表时间：
2009-04-30
影响因子：
2.3
通讯作者：
Pilowsky, Paul M.
中科院分区：
文献类型：
--
作者：
McMullan, Simon;Dick, Thomas E.;Farnham, Melissa M. J.;Pilowsky, Paul M.
围绕压力感受器激活的呼吸反应存在争议。尽管影响呼吸的许多反射（例如化学反射和伤害性反射）经常影响心血管参数，但通常认为压力反射刺激在正常生理限度内的作用仅影响血压和心率。尽管先前的作者已经报道压力感受器激活可以影响呼吸活动，但对呼吸频率和振幅的影响是高度可变的，并且由血压操纵引起的灌注变化可以解释所观察到的影响。在这里，我们确定了呼吸的影响，激活动脉压力感受器静脉注射苯肾上腺素或血管紧张素II，或通过电刺激的主动脉降压神经（ADN）。在麻醉的切断迷走神经的大鼠中，1、2和4秒的强直性ADN刺激引起吸气时间（TI）增加3.1 ± 1.1%、11.2 ± 13.6%和21.9 ± 8.9%，呼气时间分别增加23.4 ± 15.7%和34.6 ± 20.9%（P < 0.05），但对膈神经记录到的爆发波振幅无影响。在静脉注射PE（TE：+26.1 ± 9.1%，P<0.01）引起的升压试验后观察到类似的效应，但Ang II没有。间歇性ADN刺激（单脉冲，1 Hz）在低呼吸驱动期间显著增加TI的变异性（P < 0.05），而不显著影响任何其他参数。我们提出，一个特定的压力感受器呼吸反应存在，是独立于血流的变化。与压力感受器刺激对交感神经活动的影响相反，压力呼吸反应是微妙的，并且高度依赖于呼吸驱动。
Controversy surrounds the respiratory responses to baroreceptor activation. Although many reflexes that effect respiration (e.g. chemoreflexes and nociceptive reflexes) frequently affect cardiovascular parameters, the effect of baroreflex stimulation within normal physiological limits is generally considered to affect only blood pressure and heart rate. Even though previous authors have reported that baroreceptor activation can affect respiratory activity, the effects on respiratory frequency and amplitude are highly variable, and changes in perfusion evoked by blood pressure manipulation could account for the observed effects. Here, we determined the respiratory effects of activating arterial baroreceptors by intravenous injection of phenylephrine or angiotensin II, or by electrical stimulation of the aortic depressor nerve (ADN). In urethane-anaesthetized vagotomized rats, 1, 2 and 4 second trains of tetanic ADN stimulation evoked 3.1 ± 1.1%, 11.2 ± 13.6% and 21.9 ± 8.9% increases in inspiratory (TI) time and 26.5 ± 18%, 23.4 ± 15.7% and 34.6 ± 20.9% increases in expiratory (TE) time respectively (P < 0.05 in both cases), but no effect on the amplitude of bursts recorded in the phrenic nerve. Similar effects were observed following pressor trials evoked by intravenous PE (TE: +26.1 ± 9.1%, P<0.01), but not Ang II. Intermittent ADN stimulation (single pulse, 1 Hz) significantly increased the variability of TI during periods of low respiratory drive (P < 0.05) without significantly affecting any other parameters. We propose that a specific baroreceptor-respiratory response exists that is independent of changes in blood flow. In contrast to the effects of baroreceptor stimulation on sympathetic nerve activity, the baro-respiratory response is subtle and highly dependent on respiratory drive.
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影响因子：
3.3
作者：
BISHOP, B
通讯作者：
BISHOP, B
影响因子：
3.3
作者：
DOVE, EL;KATONA, PG
通讯作者：
KATONA, PG
DOI：
10.2170/jjphysiol.48.261
发表时间：
1998-08-01
期刊：
JAPANESE JOURNAL OF PHYSIOLOGY
影响因子：
--
作者：
Li, WM;Liu, X;Sato, A
通讯作者：
Sato, A
影响因子：
20.1
作者：
BRUNNER, MJ;SUSSMAN, MS;SHOUKAS, AA
通讯作者：
SHOUKAS, AA
影响因子：
--
作者：
FREGOSI, RF
通讯作者：
FREGOSI, RF