Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner
Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner
复制标题
模块化谱域光学相干断层扫描仪的设计和实现指南
DOI：
10.1155/2018/3726207
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发表时间：
2018
影响因子：
1.7
通讯作者：
R. Pashaie
中科院分区：
文献类型：
--
作者：
Farid Atry;I. D. L. Rosa;K. Rarick;R. Pashaie
在过去的几十年里，谱域光学相干断层扫描（SD-OCT）已经成为一种广泛流行的成像技术，被用于许多研究和临床应用。尽管该领域发展如此迅速，但由于商业上可用的系统的成本或可扩展性，或者由于缺乏光学领域的基本知识来开发适合特定应用的定制扫描仪，该技术还没有被许多研究实验室容易地获得。本文旨在提供一个典型的SD-OCT扫描器的设计和开发过程中的详细讨论。多个设计参数的影响，为主要的光学和光学机械部件，对成像系统的整体性能进行了分析和讨论，提供作为一个定制的SD-OCT系统的发展的指导方针。虽然这篇文章可以概括为不同的应用，我们将展示一个SD-OCT系统的设计和在体内脑成像的代表性结果。我们解释程序来测量的轴向和横向分辨率和系统的视野，并了解实验和理论值之间的差异。这篇文章的具体目的是促进为研究小组构建定制SD-OCT扫描仪的过程，同时对光学设计和医学成像的概念了解最少。
In the past decades, spectral-domain optical coherence tomography (SD-OCT) has transformed into a widely popular imaging technology which is used in many research and clinical applications. Despite such fast growth in the field, the technology has not been readily accessible to many research laboratories either due to the cost or inflexibility of the commercially available systems or due to the lack of essential knowledge in the field of optics to develop custom-made scanners that suit specific applications. This paper aims to provide a detailed discussion on the design and development process of a typical SD-OCT scanner. The effects of multiple design parameters, for the main optical and optomechanical components, on the overall performance of the imaging system are analyzed and discussions are provided to serve as a guideline for the development of a custom SD-OCT system. While this article can be generalized for different applications, we will demonstrate the design of a SD-OCT system and representative results for in vivo brain imaging. We explain procedures to measure the axial and transversal resolutions and field of view of the system and to understand the discrepancies between the experimental and theoretical values. The specific aim of this piece is to facilitate the process of constructing custom-made SD-OCT scanners for research groups with minimum understanding of concepts in optical design and medical imaging.
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