Biological Characteristics and Roles of Noncoding RNAs in Milk-Derived Extracellular Vesicles.
Biological Characteristics and Roles of Noncoding RNAs in Milk-Derived Extracellular Vesicles.
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乳源性细胞外囊泡中非编码 RNA 的生物学特性和作用。
DOI：
10.1093/advances/nmaa124
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发表时间：
2020-10
影响因子：
9.3
通讯作者：
Yong-Liang Zhang
中科院分区：
文献类型：
--
作者：
Bin Zeng;Ting Chen;Jun-Yi Luo;Lin Zhang;Qian-Yun Xi;Qing-Yan Jiang;Jia-Jie Sun;Yong-Liang Zhang
细胞外小泡(EV)在细胞间蛋白质、脂类和核酸的运输中起着不同的作用，它们是细胞间通讯的媒介。EV中存在的非编码RNA(NcRNAs)，包括microRNAs、长非编码RNAs和环状RNAs，已经被发现参与复杂的相互作用网络，并调控动物的各种基因。牛奶是人类和其他哺乳动物的重要营养来源。有证据表明，牛奶来源的电动汽车含有丰富的ncRNAs，这些ncRNAs很稳定，可以传递给后代和其他消费者。目前的数据表明，牛奶EV ncRNAs与许多生物学过程之间存在强烈的联系，这些ncRNAs已经引起了越来越多的关注，并可能在接受者中发挥表观遗传调节作用，尽管仍有必要进行进一步的研究，以了解它们的确切作用。本文介绍了牛奶EV ncRNAs的基本情况，根据现有的知识对其表达谱、生物学特性和功能进行了综述，并讨论了它们的生物学作用、存在的问题和展望。我们的目的是为了更深入地了解牛奶EV ncRNAs对子代的生理影响，并为该领域未来的研究提供参考。
Extracellular vesicles (EVs) have diverse roles in the transport of proteins, lipids, and nucleic acids between cells, and they serve as mediators of intercellular communication. Noncoding RNAs (ncRNAs) that are present in EVs, including microRNAs, long noncoding RNAs, and circular RNAs, have been found to participate in complex networks of interactions and regulate a wide variety of genes in animals. Milk is an important source of nutrition for humans and other mammals. Evidence suggests that milk-derived EVs contain abundant ncRNAs, which are stable and can be transported to the offspring and other consumers. Current data suggest a strong link between milk EV ncRNAs and many biological processes, and these ncRNAs have been drawing increasing attention and might play an epigenetic regulatory role in recipients, though further research is still necessary to understand their precise roles. The present review introduces basic information about milk EV ncRNAs, summarizes their expression profiles, biological characteristics, and functions based on current knowledge, and discusses their biological roles, indeterminate issues, and perspectives. Our goal is to provide a deeper understanding of the physiological effects of milk EV ncRNAs on offspring and to provide a reference for future research in this field.
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