Executive attention networks show altered relationship with default mode network in PD.
Executive attention networks show altered relationship with default mode network in PD.
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DOI：
10.1016/j.nicl.2016.11.004
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发表时间：
2017
影响因子：
4.2
通讯作者：
Grabowski, Thomas J.
中科院分区：
文献类型：
--
作者：
Boord, Peter;Madhyastha, Tara M.;Askren, Mary K.;Grabowski, Thomas J.
关键词：
注意力功能障碍是帕金森病中常见但经常未诊断的认知障碍，可显著降低生活质量。我们试图通过功能性神经影像学来加深对注意力障碍机制的理解。在两个重复的会议，在休息状态和注意力网络测试期间，获得功能性MRI的25名非痴呆帕金森氏病患者和21名健康对照。行为和MRI对比计算的警觉，定向和执行控制组件的注意力。大脑区域显示组的注意力处理的差异被用作种子在一个单独的休息状态运行的功能连接分析。帕金森病受试者表现出更多的激活过程中增加执行的挑战，在四个区域的背侧注意和额顶叶网络，即右额叶眼场，左，右顶内沟，楔前叶。在三个区域中，我们看到静息状态与默认模式网络的连接减少。此外，虽然在健康对照组中，右侧顶内沟的较高任务激活与右侧顶内沟和楔前叶之间的静息状态连接减少相关，但在帕金森病受试者中不存在这种关系。我们的研究结果表明，默认模式和任务的积极网络之间的相互作用减弱可能会改变执行反应的加工方式在PD。PD显示执行反应中任务正性网络（TPN）激活升高。这些区域与默认网络（DN）的功能连接（FC）较低。TPN激活和TPN-DN FC在对照组中相关，但在PD中分离。
Attention dysfunction is a common but often undiagnosed cognitive impairment in Parkinson's disease that significantly reduces quality of life. We sought to increase understanding of the mechanisms underlying attention dysfunction using functional neuroimaging. Functional MRI was acquired at two repeated sessions in the resting state and during the Attention Network Test, for 25 non-demented subjects with Parkinson's disease and 21 healthy controls. Behavioral and MRI contrasts were calculated for alerting, orienting, and executive control components of attention. Brain regions showing group differences in attention processing were used as seeds in a functional connectivity analysis of a separate resting state run. Parkinson's disease subjects showed more activation during increased executive challenge in four regions of the dorsal attention and frontoparietal networks, namely right frontal eye field, left and right intraparietal sulcus, and precuneus. In three regions we saw reduced resting state connectivity to the default mode network. Further, whereas higher task activation in the right intraparietal sulcus correlated with reduced resting state connectivity between right intraparietal sulcus and the precuneus in healthy controls, this relationship was absent in Parkinson's disease subjects. Our results suggest that a weakened interaction between the default mode and task positive networks might alter the way in which the executive response is processed in PD. PD shows elevated task positive network (TPN) activation in an executive response. These regions show lower functional connectivity (FC) with the default network (DN). TPN activation and TPN-DN FC are associated in controls, but dissociated in PD.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.3233/jpd-130189
发表时间：
2013
期刊：
Journal of Parkinson's disease
影响因子：
--
作者：
Cholerton BA;Zabetian CP;Quinn JF;Chung KA;Peterson A;Espay AJ;Revilla FJ;Devoto J;Watson GS;Hu SC;Edwards KL;Montine TJ;Leverenz JB
通讯作者：
Leverenz JB
DOI：
10.1002/mds.26128
发表时间：
2015-12
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Madhyastha TM;Askren MK;Boord P;Zhang J;Leverenz JB;Grabowski TJ
通讯作者：
Grabowski TJ
影响因子：
8.6
作者：
Barone, Paolo;Antonini, Angelo;Del Dotto, Paolo
通讯作者：
Del Dotto, Paolo
影响因子：
9.9
作者：
Klein, J. C.;Eggers, C.;Hilker, R.
通讯作者：
Hilker, R.