Identification of dyslipidemia as a risk factor for sudden sensorineural hearing loss: A multicenter case-control study.
Identification of dyslipidemia as a risk factor for sudden sensorineural hearing loss: A multicenter case-control study.
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DOI：
10.1002/jcla.24067
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发表时间：
2021-12
影响因子：
2.7
通讯作者：
Hu W
中科院分区：
文献类型：
--
作者：
Li X;Chen B;Zhou X;Ye F;Wang Y;Hu W
最近，一些研究报道了血脂水平与突发性感音神经性听力损失（SSNHL）之间的关联，但在定义血脂水平与SSNHL之间的精确关联方面，个体研究之间存在相当大的差异。本研究旨在确定血脂异常与SSNHL的患病率和预后之间的可能关系。在两个独立的医学中心进行了一项病例对照研究，包括2，288名SSNHL患者和2，288名健康对照。评估临床特征和血脂参数，包括总胆固醇（CHOL）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、甘油三酯（Trig）、载脂蛋白AI（ApoAI）、载脂蛋白B（ApoB）和脂蛋白a（Lpa）。对4,576例受试者进行多变量logistic回归分析，以评估血脂谱与SSNHL之间的关系。SSNHL患者和健康对照组之间的几种常规血脂标志物包括CHOL、Trig、HDL、LDL、ApoAI、ApoB和Lpa存在显著差异。双侧SSNHL患者的血清ApoAI水平显著低于单侧SSNHL患者。二元Logistic回归分析显示，较高水平的ApoB、LDL、Trig以及较低水平的ApoAI和HDL均与SSNHL的风险增加相关。临床表征后，多变量分析表明，只有低水平的ApoB预测的可能性超过30分贝的恢复与SSNHL患者。血脂水平与SSNHL的发病率及预后有关。识别血脂异常可能会改善SSNHL风险的早期评估和管理。各种脂质和SSNHL风险的二元Logistic回归分析。虽然SSNHL患者和对照组的CHOL和Lpa浓度差异显著，但在多变量分析中，CHOL和Lpa均与SSNHL无关。ApoB水平比健康对照高5.54倍（95% CI 4.11-7.47）的受试者更可能患有SSNHL病理。与健康对照组相比，LDL和Trig水平异常的患者患SSNHL的几率增加了10%（1.10（1.03-1.18））和29%（1.29（1.22-1.35））。SSNHL患者的ApoAI水平显著低于对照组（0.16（0.13-0.21））。相反，对照受试者的HDL水平低于在SSNHL患者中观察到的水平（0.67（0.56-0.80））。
Recently, several studies have reported an association between lipid profiles and sudden sensorineural hearing loss (SSNHL), yet there is considerable variability between the individual studies in defining the precise association between serum lipids levels and SSNHL. This study sought to identify a possible relationship between dyslipidemia and the prevalence and prognosis of SSNHL. A case‐control study was carried out at two independent medical centers, including 2,288 SSNHL patients and 2,288 healthy controls. Clinical characteristics and serum lipid parameters were assessed, including total cholesterol (CHOL), high‐density lipoprotein (HDL), low‐density lipoprotein (LDL), triglycerides (Trig), apolipoprotein AI (ApoAI), apolipoprotein B (ApoB), and lipoprotein a (Lpa). Multivariate logistic regression analysis was performed to assess the relationship between lipid profiles and SSNHL in the 4,576 subjects. Significant differences were identified in several conventional serum lipid markers including CHOL, Trig, HDL, LDL, ApoAI, ApoB, and Lpa, between SSNHL patients and healthy controls. Serum ApoAI levels were significantly lower in patients with bilateral SSNHL compared to unilateral SSNHL. Binary logistic regression analysis revealed that higher levels of ApoB, LDL, Trig, and lower levels of ApoAI and HDL were all associated with an increased risk of SSNHL. After clinical characterization, multivariate analysis showed that only low levels of ApoB predicted likelihood of a recovery of more than 30 dB among patients with SSNHL. Serum lipids are associated with the incidence and prognosis of SSNHL. Identification of dyslipidemia may improve early evaluation and management of SSNHL risks. Binary logistic regression analysis of various lipids and SSNHL risk. Although CHOL and Lpa concentrations differed significantly between SSNHL patients and control subjects, neither the CHOL nor Lpa was related to SSNHL in multivariate analysis. Subjects with ApoB levels 5.54‐fold (95% CI 4.11–7.47) higher than that of healthy controls were more likely to have SSNHL pathology. Patients with abnormal LDL and Trig levels had a 10% (1.10 (1.03–1.18)) and 29% (1.29 (1.22–1.35)) increased odds of having SSNHL compared with healthy controls. Levels of ApoAI in patients with SSNHL were significantly lower (0.16 (0.13–0.21)) than that of control subjects. Conversely, HDL levels of control subjects were lower than those observed in patients with SSNHL (0.67 (0.56–0.80)).
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影响因子：
10.4
作者：
Marcucci, R;Liotta, AA;Prisco, D
通讯作者：
Prisco, D
影响因子：
6.7
作者：
Rudack, C;Langer, C;Walter, M
通讯作者：
Walter, M
影响因子：
1.6
作者：
Fusconi, Massimo;Chistolini, Antonio;de Vincentiis, Marco
通讯作者：
de Vincentiis, Marco
影响因子：
1.4
作者：
Cadoni, Gabriella;Scorpecci, Alessandro;Lippa, Silvio
通讯作者：
Lippa, Silvio
外周血中的高总胆固醇与特发性突然的感觉性听力损失的听力恢复较差相关。
影响因子：
3.7
作者：
Quaranta N;Squeo V;Sangineto M;Graziano G;Sabbà C
通讯作者：
Sabbà C