Commonalities in Metabolic Reprogramming between Tobacco Use and Oral Cancer.
Commonalities in Metabolic Reprogramming between Tobacco Use and Oral Cancer.
复制标题
吸烟与口腔癌代谢重编程的共性
DOI：
10.3390/ijerph191610261
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发表时间：
2022-08-18
影响因子：
--
通讯作者：
Sumner, Susan
中科院分区：
文献类型：
--
作者：
Rushing, Blake R.;Tilley, Spencer;Molina, Sabrina;Schroder, Madison;Sumner, Susan
烟草使用是一个主要的公共卫生问题，与包括癌症在内的无数疾病有关。烟草使用与口腔癌之间的联系非常密切，使烟草使用成为口腔癌的主要风险因素之一。虽然这种关联是众所周知的，但烟草使用导致的潜在生化变化，以及这种变化如何与口腔癌的代谢表型联系在一起，尚不清楚。为了解决这一知识差距，结合文献综述和代谢组学研究，以确定烟草使用和口腔癌之间代谢紊乱的共性。对吸烟者和非吸烟者、健康和恶性口腔组织以及培养的口腔细胞的合并参考尿液进行代谢组学分析，其中使用或不使用众所周知的烟草致癌物4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁酮（NNK）。氨基酸代谢、碳水化合物/氧化磷酸化、脂肪酸氧化、核苷酸代谢、类固醇代谢和维生素代谢的改变被发现在烟草使用和口腔癌之间共享。这些结果支持烟草使用代谢重编程口腔细胞，以支持通过这些途径的恶性转化的结论。这些代谢重编程事件可能是预防或治疗烟草使用引起的口腔癌的潜在目标。
Tobacco use is a major public health concern and is linked to myriad diseases, including cancer. The link between tobacco use and oral cancer, specifically, is very strong, making tobacco use one of the primary risk factors for oral cancer. While this association is well known, the underlying biochemical changes that result from tobacco use, and how this links to metabolic phenotypes of oral cancer, is not well understood. To address this knowledge gap, a combination of literature reviews and metabolomics studies were performed to identify commonalities in metabolic perturbations between tobacco use and oral cancers. Metabolomics analysis was performed on pooled reference urine from smokers and non-smokers, healthy and malignant oral tissues, and cultured oral cells with or without treatment of the well-known tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Alterations in amino acid metabolism, carbohydrates/oxidative phosphorylation, fatty acid oxidation, nucleotide metabolism, steroid metabolism, and vitamin metabolism were found to be shared between tobacco use and oral cancer. These results support the conclusion that tobacco use metabolically reprograms oral cells to support malignant transformation through these pathways. These metabolic reprogramming events may be potential targets to prevent or treat oral cancers that arise from tobacco use.
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影响因子：
4.5
作者：
Li S;Li Y;Rushing BR;Harris SE;McRitchie SL;Jones JC;Dominguez D;Sumner SJ;Dohlman HG
通讯作者：
Dohlman HG
影响因子：
2.5
作者：
Keser, Aysegul;Nesil, Tanseli;Pogun, Sakire
通讯作者：
Pogun, Sakire
影响因子：
3.7
作者：
Lohavanichbutr P;Zhang Y;Wang P;Gu H;Nagana Gowda GA;Djukovic D;Buas MF;Raftery D;Chen C
通讯作者：
Chen C
影响因子：
21.3
作者：
Boroughs LK;DeBerardinis RJ
通讯作者：
DeBerardinis RJ
影响因子：
--
作者：
Doldo E;Costanza G;Agostinelli S;Tarquini C;Ferlosio A;Arcuri G;Passeri D;Scioli MG;Orlandi A
通讯作者：
Orlandi A