Vitamin A, cancer treatment and prevention: the new role of cellular retinol binding proteins.
Vitamin A, cancer treatment and prevention: the new role of cellular retinol binding proteins.
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DOI：
10.1155/2015/624627
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发表时间：
2015
影响因子：
--
通讯作者：
Orlandi A
中科院分区：
文献类型：
--
作者：
Doldo E;Costanza G;Agostinelli S;Tarquini C;Ferlosio A;Arcuri G;Passeri D;Scioli MG;Orlandi A
视黄醇和维生素A衍生物影响细胞分化、增殖和凋亡，并在广泛的生物过程中发挥重要的生理作用。视黄醇是从动物源性食物中获得的。视黄醇衍生物是视力的基础，而视黄酸是皮肤和骨骼生长所必需的。细胞内类维生素A的生物利用度是由特定的细胞质视黄醇和视黄酸结合蛋白（CRBP和CRABP）的存在下进行调节。CRBP-1是最广泛的CRBP同种型，是一种在许多组织中广泛表达和进化保守的小的15 KDa胞质蛋白。CRBP-1作为分子伴侣，调节视黄醇的摄取、随后的酯化和生物利用度。CRBP-1在伤口愈合和动脉组织重塑过程中起主要作用。在过去的几年中，CRBP-1相关的类维生素A信号在癌症进展中的作用成为几项研究的对象。CRBP-1下调与乳腺癌、卵巢癌和鼻咽癌中恶性表型的增加有关。CRBP-1的再表达增加了体外卵巢癌细胞对视黄醇的敏感性并降低了细胞活力。需要进一步的研究来探索新的治疗策略，旨在恢复CRBP-1介导的细胞内视黄醇运输以及CRBP-1表达在癌症患者筛选更个性化和有效的类维生素A治疗中的意义。
Retinol and vitamin A derivatives influence cell differentiation, proliferation, and apoptosis and play an important physiologic role in a wide range of biological processes. Retinol is obtained from foods of animal origin. Retinol derivatives are fundamental for vision, while retinoic acid is essential for skin and bone growth. Intracellular retinoid bioavailability is regulated by the presence of specific cytoplasmic retinol and retinoic acid binding proteins (CRBPs and CRABPs). CRBP-1, the most diffuse CRBP isoform, is a small 15 KDa cytosolic protein widely expressed and evolutionarily conserved in many tissues. CRBP-1 acts as chaperone and regulates the uptake, subsequent esterification, and bioavailability of retinol. CRBP-1 plays a major role in wound healing and arterial tissue remodelling processes. In the last years, the role of CRBP-1-related retinoid signalling during cancer progression became object of several studies. CRBP-1 downregulation associates with a more malignant phenotype in breast, ovarian, and nasopharyngeal cancers. Reexpression of CRBP-1 increased retinol sensitivity and reduced viability of ovarian cancer cells in vitro. Further studies are needed to explore new therapeutic strategies aimed at restoring CRBP-1-mediated intracellular retinol trafficking and the meaning of CRBP-1 expression in cancer patients' screening for a more personalized and efficacy retinoid therapy.
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