The influence of aging on the methylation status of brain‐derived neurotrophic factor gene in blood

The influence of aging on the methylation status of brain‐derived neurotrophic factor gene in blood
复制标题

衰老对血液中脑源性神经营养因子基因甲基化状态的影响

DOI：
10.1002/gps.4927
复制
发表时间：
2018
期刊：
International Journal of Geriatric Psychiatry
影响因子：
4
通讯作者：
S. Morinobu
S. Morinobu
中科院分区：
医学2区
文献类型：
--
作者：
K. Ihara;Manabu Fuchikami;M. Hashizume;S. Okada;H. Kawai;S. Obuchi;H. Hirano;Y. Fujiwara;M. Hachisu;Hongyong Kim;S. Morinobu

文献摘要

参考文献

相似文献

脑源性神经营养因子（BDNF）参与成年人和老年人精神疾病的病理生理学，因此，已广泛研究了外周组织（包括血液）中BDNF基因的DNA甲基化（DNAm），以开发精神疾病的有用生物标志物。然而，迄今为止的研究还没有研究过年龄对血液中BDNF基因DNAm的影响。在这种情况下，我们测量了BDNF基因外显子I启动子CpG岛中39个CpG单位的DNAm。
Brain‐derived neurotrophic factor (BDNF) is involved in the pathophysiology of psychiatric disorders in adults and elderly individuals, and as a result, the DNA methylation (DNAm) of the BDNF gene in peripheral tissues including blood has been extensively examined to develop a useful biomarker for psychiatric disorders. However, studies to date have not previously investigated the effect of age on DNAm of the BDNF gene in blood. In this context, we measured DNAm of 39 CpG units in the CpG island at the promoter of exon I of the BDNF gene.
Analysis of the machinery and intermediates of the 5 hmC ‐ mediated DNA demethylation pathway in aging on samples from the
DOI： --
发表时间： 2016
期刊： --
影响因子： --
作者：
Valentini;Zampieri;Malavolta;Bacalini;Roberta;V. Calabrese;Guastafierro;Reale;Franceschi;Hervonen;Koller;Bernhardt;Slagboom;Toussaint;K Sikora;Gonos;Breusing;Grune;Jansen;Dollé;Moreno;Villanueva;Sindlinger;Bürkle;Ciccarone;Paola;Caiafa
通讯作者： Valentini;Zampieri;Malavolta;Bacalini;Roberta;V. Calabrese;Guastafierro;Reale;Franceschi;Hervonen;Koller;Bernhardt;Slagboom;Toussaint;K Sikora;Gonos;Breusing;Grune;Jansen;Dollé;Moreno;Villanueva;Sindlinger;Bürkle;Ciccarone;Paola;Caiafa
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects
DOI： 10.1093/hmg/ddt511
发表时间： 2014-03-01
期刊： HUMAN MOLECULAR GENETICS
影响因子： 3.5
作者：
McClay, Joseph L.;Aberg, Karolina A.;Van den Oord, Edwin J. C. G.
通讯作者： Van den Oord, Edwin J. C. G.
BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex
DOI： 10.1016/s0165-3806(02)00540-0
发表时间： 2002-12-15
期刊： DEVELOPMENTAL BRAIN RESEARCH
影响因子： --
作者：
Webster, MJ;Weickert, CS;Kleinman, JE
通讯作者： Kleinman, JE
Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.
DOI： --
发表时间： 2000
期刊： Neurology
影响因子： 9.9
作者：
Antonio Lobo;L. Launer;L. Fratiglioni;K. Andersen;A. Carlo;M. Breteler;J. Copeland;J. Dartigues-J.-Darti
通讯作者： Antonio Lobo;L. Launer;L. Fratiglioni;K. Andersen;A. Carlo;M. Breteler;J. Copeland;J. Dartigues-J.-Darti
Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder.
DOI： 10.1016/j.jpsychires.2011.01.013
发表时间： 2011-07
期刊： Journal of psychiatric research
影响因子： 4.8
作者：
Roth TL;Zoladz PR;Sweatt JD;Diamond DM
通讯作者： Diamond DM