The Projection From Ventral CA1, Not Prefrontal Cortex, to Nucleus Accumbens Core Mediates Recent Memory Retrieval of Cocaine-Conditioned Place Preference.
The Projection From Ventral CA1, Not Prefrontal Cortex, to Nucleus Accumbens Core Mediates Recent Memory Retrieval of Cocaine-Conditioned Place Preference.
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从腹侧 CA1（而非前额皮质）到伏核核心的投射介导可卡因条件位置偏好的近期记忆检索
DOI：
10.3389/fnbeh.2020.558074
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发表时间：
2020
影响因子：
3
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Zhou Y;Yan E;Cheng D;Zhu H;Liu Z;Chen X;Ma L;Liu X
药物配对线索通过表达觅药行为诱导记忆提取，这对药物戒断提出了重大挑战。神经回路如何协调药物记忆恢复仍然不清楚。在这里，我们报告说，暴露的可卡因条件性位置偏爱（CPP）的训练室进行增加的神经元活动的核心，丘脑腹侧CA 1（vCA 1），内侧前额叶皮层（mPFC），所示的升高pERK和c-Fos水平。在vCA 1和AcbC，但不是mPFC的神经元活性的化学发生抑制，减少了可卡因配对的隔室中花费的时间，这表明vCA 1和AcbC是所需的可卡因-CPP记忆的检索和可卡因记忆存储招募的关键节点。此外，化学发生抑制的AcbC投射vCA 1神经元，但不是AcbC投射mPFC神经元，可卡因CPP的表达下降。vCA 1-AcbC投射的光遗传抑制，而不是mPFC-AcbC投射，也减少了对可卡因配对隔室的偏好。综上所述，提示诱导的可卡因记忆的自然回忆依赖于vCA 1-AcbC回路。从vCA 1到AcbC的连接可能存储了记忆提取所必需的线索-可卡因奖励关联的信息。因此，这些数据提供了深入了解神经回路的基础上检索药物相关的记忆。
Drug-paired cues inducing memory retrieval by expressing drug-seeking behaviors present a major challenge to drug abstinence. How neural circuits coordinate for drug memory retrieval remains unclear. Here, we report that exposure of the training chamber where cocaine-conditioned place preference (CPP) was performed increased neuronal activity in the core of nucleus accumbens (AcbC), ventral CA1 (vCA1), and medial prefrontal cortex (mPFC), as shown by elevated pERK and c-Fos levels. Chemogenetic inhibition of neuronal activity in the vCA1 and AcbC, but not mPFC, reduced the time spent in the cocaine-paired compartment, suggesting that the vCA1 and AcbC are required for the retrieval of cocaine-CPP memory and are key nodes recruited for cocaine memory storage. Furthermore, chemogenetic inhibition of the AcbC-projecting vCA1 neurons, but not the AcbC-projecting mPFC neurons, decreased the expression of cocaine-CPP. Optogenetic inhibition of the vCA1–AcbC projection, but not the mPFC–AcbC projection, also reduced the preference for the cocaine-paired compartment. Taken together, the cue-induced natural recall of cocaine memory depends on vCA1–AcbC circuits. The connectivity from the vCA1 to the AcbC may store the information of the cue–cocaine reward association critically required for memory retrieval. These data thus provide insights into the neural circuit basis of retrieval of drug-related memory.
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影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
3.4
作者：
Capriles, N;Rodaros, D;Stewart, J
通讯作者：
Stewart, J
影响因子：
15.9
作者：
Goto, Yukiori;Grace, Anthony A.
通讯作者：
Grace, Anthony A.
DOI：
10.1126/science.1214985
发表时间：
2012-03-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Garner AR;Rowland DC;Hwang SY;Baumgaertel K;Roth BL;Kentros C;Mayford M
通讯作者：
Mayford M