Variation in frequency of the virulence-factor gene in Escherichia coli clones colonizing the stools and urinary tracts of healthy prepubertal girls.
Variation in frequency of the virulence-factor gene in Escherichia coli clones colonizing the stools and urinary tracts of healthy prepubertal girls.
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定植于健康青春期前女孩的粪便和尿道的大肠杆菌克隆毒力因子基因频率的变化。
DOI：
10.1086/377643
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Stapleton,A
中科院分区：
文献类型：
--
作者：
Schlager,TheresaA;Whittam,ThomasS;Hendley,JO;Bhang,JuneL;Wobbe,CherylL;Stapleton,A
为了提供健康宿主中大肠杆菌毒力表达的信息，每周从生活在一个小农村社区的健康3-6岁女孩中收集粪便、尿道周围和尿液样本。在粪便标本中确定显性和非显性克隆，并确定毒力因子的表达。我们发现健康的女孩通常都有显性克隆。P粘附素、溶血素和I型粘附素通常存在于粪便中的克隆和尿路中的克隆中。此外，毒力因子的表达，在粪便中的显性和非显性克隆，从一周到一周的变化。P粘附素的存在是粪便中显性克隆持续存在的标志物，并且与在尿路中检测到非显性克隆的可能性增加相关。I型粘附素在粪便菌株中普遍存在，菌毛开关的方向既处于“关闭”位置，也处于“打开”和“关闭”位置。综上所述，健康女童肠道植物群复杂，毒力表达变化频繁
To provide information on virulence expression ofEscherichia coliin healthy hosts, stool, periurethral, and urine samples were collected weekly from healthy 3–6-year-old girls who lived in a small rural community. Dominant and nondominant clones were defined in stool specimens, and the expression of virulence factors was determined. We found that healthy girls commonly shared dominant clones. P adhesin, hemolysin, and type I adhesin were commonly found in clones in the stool and in clones in the urinary tract. In addition, expression of virulence factors, among both dominant and nondominant clones in the stool, changed from week to week. The presence of P adhesin was a marker for the persistence of a dominant clone in the stool and was associated with an increased likelihood that a nondominant clone would be detected in the urinary tract. Type I adhesin was ubiquitous among stool strains, with orientation of the fimbrial switch being both in the “off” position and in both the “on” and “off” positions. In summary, the intestinal flora of healthy girls is complex, with frequent changes in virulence expression
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DOI：
10.1016/s0140-6736(81)92797-5
发表时间：
1981-12
期刊：
The Lancet
影响因子：
--
作者：
G. Källenius;S. Svenson;H. Hultberg;R. Möllby;I. Helin;B. Cedergren;J. Winberg
通讯作者：
G. Källenius;S. Svenson;H. Hultberg;R. Möllby;I. Helin;B. Cedergren;J. Winberg
P菌毛和需氧菌素作为巴基斯坦婴儿大肠杆菌的肠道定植因子
影响因子：
4.2
作者：
F. Nowrouzian;A. Wold;I. Adlerberth
通讯作者：
I. Adlerberth
P 菌毛和 1 型菌毛对于大肠杆菌在人类肠道中持久存在的重要性
影响因子：
4.2
作者：
K. Tullus;I. Kühn;I. Ørskov;F. Ørskov;Roland Möllby
通讯作者：
Roland Möllby
膀胱炎患者尿液中大肠杆菌毒力因子的分布
影响因子：
2.6
作者：
Shingo Yamamoto;T. Tsukamoto;A. Terai;H. Kurazono;Y. Takeda;O. Yoshida
通讯作者：
O. Yoshida
尿路致病性大肠杆菌菌株中的 P 菌毛克隆
影响因子：
3.1
作者：
V. Väisänen;J. Elo;E. Väisänen;A. Siitonen;I. Orskov;F. Orskov;S. Svenson;P. Mäkelä;Timo K. Korhonen
通讯作者：
Timo K. Korhonen