Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos, Peru.
Concentrations of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in women exposed to woodsmoke in a cookstove intervention study in San Marcos, Peru.
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DOI：
10.1016/j.envint.2013.08.013
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发表时间：
2013-10
影响因子：
11.8
通讯作者：
Naeher, Luke P.
中科院分区：
文献类型：
--
作者：
Commodore, Adwoa A.;Zhang, Junfeng (Jim);Chang, Yan;Hartinger, Stella M.;Lanata, Claudio F.;Maesezahl, Daniel;Gil, Ana I.;Hall, Daniel B.;Aguilar-Villalobos, Manuel;Vena, John E.;Wang, Jia-Sheng;Naeher, Luke P.
世界上近一半的人口由于长时间接近无通风的烹饪炉火而暴露于家庭空气污染（HAP）。通过调查对照组和干预组炉灶使用者的DNA氧化（8-羟基-2 ′-脱氧鸟苷[8-OHdG]）和脂质过氧化（8-异前列烷）生物标志物与木材烟雾暴露之间的关系，研究木材烟雾暴露对氧化应激的影响。在秘鲁卡哈马卡地区圣马科斯省51个社区的社区随机对照试验框架内进行了HAP暴露评估。对45名对照组和39名干预组炉灶使用者进行48小时HAP暴露评估后的首次晨尿进行8-OHdG和8-异前列烷分析。进行一般线性模型和相关性分析。在所有研究受试者（n=84）中，8-OHdG的尿氧化应激生物标志物范围为11.2 - 2270.0 μg/g肌酐（中位数：132.6 μg/g肌酐），8-异前列烷的尿氧化应激生物标志物范围为0.1 - 4.5 μg/g肌酐（中位数：0.8 μg/g肌酐）。在所有受试者中控制了社区交通和暴露于火的食物的影响后，烹饪时间与尿8-OHdG呈弱相关，但呈正相关（r=0.29，p=0.01，n=80）。受试者的实时个人CO暴露与8-OHdG呈负相关，特别是采样期间最大30秒CO暴露（r=-0.32，p=0.001，n=73）。48小时时间积分的个人PM2.5呈负相关，但在控制了家到道路的距离的影响后，与尿8-异前列烷略有相关（r=-0.21，p=0.09，n=69）。现有文献中报告的尿8-异前列烷水平与当前研究中发现的结果相当。然而，与现有文献中的8-OHdG排泄数据相比，尿8-OHdG水平相对较高。结果表明，这些秘鲁妇女长期暴露于木材烟雾中的持续全身氧化应激。
Nearly half of the world’s population is exposed to household air pollution (HAP) due to long hours spent in close proximity to unvented cooking fires. The effect of woodsmoke exposure on oxidative stress was examined by investigating the association between woodsmoke exposure and biomarkers of DNA oxidation (8-hydroxy-2′-deoxyguanosine [8-OHdG]) and lipid peroxidation (8-isoprostane) among control and intervention stove users. HAP exposure assessment was conducted within the framework of a community-randomized controlled trial of 51 communities in San Marcos Province, Cajamarca Region, Peru. The first morning urine voids after 48hr HAP exposure assessment from a subset of 45 control and 39 intervention stove users were analyzed for 8-OHdG and 8-isoprostane. General linear models and correlation analyses were performed. Urinary oxidative stress biomarkers ranged from 11.2 to 2270.0 μg/g creatinine (median: 132.6 μg/g creatinine) for 8-OHdG and from 0.1 to 4.5 μg/g creatinine (median: 0.8 μg/g creatinine) for 8-isoprostane among all study subjects (n=84). After controlling for the effects of traffic in the community and eating food exposed to fire among all subjects, cooking time was weakly, but positively associated with urinary 8-OHdG (r=0.29, p=0.01, n=80). Subjects’ real-time personal CO exposures were negatively associated with 8-OHdG, particularly the maximum 30-second CO exposure during the sampling period (r=−0.32, p=0.001, n=73). 48hr time integrated personal PM2.5 was negatively, but marginally associated with urinary 8-isoprostane (r=−0.21, p=0.09, n=69) after controlling for the effect of distance of homes to the road. Urinary 8-isoprostane levels reported in the available literature are comparable to results found in the current study. However there were relatively high levels of urinary 8-OHdG compared to data in the available literature for 8-OHdG excretion. Results suggest a sustained systemic oxidative stress among these Peruvian women chronically exposed to wood smoke.
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尿液8-羟基-2'-脱氧鸟苷是暴露于细颗粒的工人中氧化DNA损伤的生物标志物。
影响因子：
10.4
作者：
Kim JY;Mukherjee S;Ngo LC;Christiani DC
通讯作者：
Christiani DC
DOI：
10.1179/2049396712y.0000000014
发表时间：
2013-03-01
影响因子：
--
作者：
Commodore, Adwoa A.;Hartinger, Stella M.;Naeher, Luke P.
通讯作者：
Naeher, Luke P.
影响因子：
5.1
作者：
Banerjee, Anirban;Mondal, Nandan Kumar;Ray, Manas Ranjan
通讯作者：
Ray, Manas Ranjan
影响因子：
7.4
作者：
Liang, YL;Wei, P;Heward, CB
通讯作者：
Heward, CB
DOI：
10.1111/j.1742-7843.2006.pto_217.x
发表时间：
2006-05-01
影响因子：
3.1
作者：
Kimura, Shingo;Yamauchi, Hiroshi;Ogino, Keiki
通讯作者：
Ogino, Keiki