Abnormal task modulation of oscillatory neural activity in schizophrenia.
Abnormal task modulation of oscillatory neural activity in schizophrenia.
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DOI：
10.3389/fpsyg.2013.00540
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发表时间：
2013
影响因子：
3.8
通讯作者：
Javitt DC
中科院分区：
文献类型：
--
作者：
Dias EC;Bickel S;Epstein ML;Sehatpour P;Javitt DC
精神分裂症患者有认知功能缺陷，这是该疾病的核心特征。AX-CPT是研究精神分裂症认知功能的常用方法，患者具有特征性的行为和ERP反应模式。在AX-CPT中，当闪现的提示“A”后面跟着目标“X”时，受试者会做出反应，而忽略其他字母组合。患者表现出降低的命中率“去”试验，并增加假警报的序列，需要抑制的优势反应。EEG记录显示感觉（P1/N1）以及后来的认知成分（N2，P3，CNV）减少。行为缺陷与感觉功能障碍的相关性最强。振荡分析提供了超过标准ERP分析的关于感觉/认知处理的关键信息。最近对健康志愿者在AX-CPT期间单次试验中诱导振荡活动的分析显示，θ、α和β频率的特征反应模式与特定的感觉和认知过程有关。在试验过程中，α和β调制以及额叶皮层的β调制与反应时间相关。在这项研究中，EEG数据从18名精神分裂症患者和13名对照组在AX-CPT性能，和单次试验分解的信号产生的功率在目标波长。显著的任务相关的事件相关去极化（ERD）在顶枕叶皮层与线索的感觉编码相关的α和β频带中观察到。这种调节在β患者中减少，但不是α。此外，在运动皮层上观察到显著的β ERD，与反应的运动准备相关，并且在患者中也减少。这些研究结果表明，受损的动态调制的β频率节律的精神分裂症，并表明，振荡活动的失败可能是精神分裂症，反过来又有助于认知缺陷的感觉信息处理受损的基础。
Schizophrenia patients have deficits in cognitive function that are a core feature of the disorder. AX-CPT is commonly used to study cognition in schizophrenia, and patients have characteristic pattern of behavioral and ERP response. In AX-CPT subjects respond when a flashed cue “A” is followed by a target “X,” ignoring other letter combinations. Patients show reduced hit rate to “go” trials, and increased false alarms to sequences that require inhibition of a prepotent response. EEG recordings show reduced sensory (P1/N1), as well as later cognitive components (N2, P3, CNV). Behavioral deficits correlate most strongly with sensory dysfunction. Oscillatory analyses provide critical information regarding sensory/cognitive processing over and above standard ERP analyses. Recent analyses of induced oscillatory activity in single trials during AX-CPT in healthy volunteers showed characteristic response patterns in theta, alpha, and beta frequencies tied to specific sensory and cognitive processes. Alpha and beta modulated during the trials and beta modulation over the frontal cortex correlated with reaction time. In this study, EEG data was obtained from 18 schizophrenia patients and 13 controls during AX-CPT performance, and single trial decomposition of the signal yielded power in the target wavelengths. Significant task-related event-related desynchronization (ERD) was observed in both alpha and beta frequency bands over parieto-occipital cortex related to sensory encoding of the cue. This modulation was reduced in patients for beta, but not for alpha. In addition, significant beta ERD was observed over motor cortex, related to motor preparation for the response, and was also reduced in patients. These findings demonstrate impaired dynamic modulation of beta frequency rhythms in schizophrenia, and suggest that failures of oscillatory activity may underlie impaired sensory information processing in schizophrenia that in turn contributes to cognitive deficits.
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影响因子：
2.9
作者：
Grützner C;Wibral M;Sun L;Rivolta D;Singer W;Maurer K;Uhlhaas PJ
通讯作者：
Uhlhaas PJ
影响因子：
2.7
作者：
Fallani, Fabrizio De Vico;Maglione, Antongiulio;Micheloyannis, Sifis
通讯作者：
Micheloyannis, Sifis
影响因子：
5.4
作者：
COHEN, JD;SERVANSCHREIBER, D
通讯作者：
SERVANSCHREIBER, D
影响因子：
--
作者：
Butler, PD;Zemon, V;Javitt, DC
通讯作者：
Javitt, DC
影响因子：
3.7
作者：
Hong, L. Elliot;Buchanan, Robert W.;Summerfelt, Ann
通讯作者：
Summerfelt, Ann