An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample.
An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample.
复制标题
DOI：
10.1002/jbmr.192
复制
发表时间：
2011-01
影响因子：
6.2
通讯作者：
Pietilainen, Kirsi H.
中科院分区：
文献类型：
--
作者：
Bogl, Leonie H.;Latvala, Antti;Kaprio, Jaakko;Sovijarvi, Olli;Rissanen, Aila;Pietilainen, Kirsi H.
本研究的目的是研究脂肪量（FM）和瘦质量（LM）与骨矿物质密度（BMD）的关系，而不受遗传效应的影响。我们还评估了遗传和环境影响在多大程度上解释了这些表型之间的关联。使用双能x线吸收仪测量了57对同卵双胞胎和92对同性异卵双胞胎的身体组成和骨密度，年龄在23至31岁之间，选择代表身体质量指数（BMI； 0至15.2 kg/m2）的大范围内的对内差异。遗传率估计根据身高和性别进行了调整。在多元线性回归分析中，调整性别和身高差异后，FM和LM的对内差异与大多数骨骼部位的骨密度对内差异独立相关。在同卵和异卵对中，LM比FM更能预测全身骨密度（p < 0.01）。累加性遗传因素分别解释了87%（95%置信区间（CI） 80%-91%）、81% （95% CI 70%-88%）和61% （95% CI 41%-75%）的全身骨密度、LM和FM变异。根据骨骼部位的不同，可加性遗传因素在LM和BMD之间的协方差中占69%至88%，在FM和BMD之间的协方差中占42%至72%。LM与全身骨密度的遗传相关性（rg = 0.46, 95% CI 0.32 ~ 0.58）大于FM与全身骨密度的遗传相关性（rg = 0.25, 95% CI 0.05 ~ 0.42）。总之，我们的数据表明，骨密度峰值受后天体重和遗传因素的影响。在年轻的成年期，LM和BMD可能比FM和BMD有更多的共同基因。©2011美国骨与矿物研究学会。
The purpose of this study was to investigate the relationship of fat mass (FM) and lean mass (LM) with bone mineral density (BMD) independent of genetic effects. We also assessed the extent to which genetic and environmental influences explain the associations between these phenotypes. Body composition and BMD were measured using dual-energy X-ray absorptiometry in 57 monozygotic and 92 same-sex dizygotic twin pairs, aged 23 to 31 years, chosen to represent a wide range of intrapair differences in body mass index (BMI; 0 to 15.2 kg/m2). Heritability estimates were adjusted for height and gender. In multiple linear regression analysis, intrapair differences in both FM and LM were independently associated with intrapair differences in BMD at most skeletal sites after adjustment for gender and differences in height. Within monozygotic and dizygotic pairs, LM was a significantly stronger predictor of whole-body BMD than FM (p < .01). Additive genetic factors explained 87% [95% confidence interval (CI) 80%–91%), 81% (95% CI 70%–88%), and 61% (95% CI 41%–75%) of the variation in whole-body BMD, LM, and FM, respectively. Additive genetic factors also accounted for 69% to 88% of the covariance between LM and BMD and for 42% to 72% of the covariance between FM and BMD depending on the skeletal site. The genetic correlation between LM and whole-body BMD (rg = 0.46, 95% CI 0.32–0.58) was greater than that of FM and whole-body BMD (rg = 0.25, 95% CI 0.05–0.42). In conclusion, our data indicate that peak BMD is influenced by acquired body weight as well as genetic factors. In young adulthood, LM and BMD may have more genes in common than do FM and BMD. © 2011 American Society for Bone and Mineral Research.
登录
查看更多内容
影响因子：
5.8
作者：
Bustamante, M.;Nogues, X.;Balcells, S.
通讯作者：
Balcells, S.
影响因子：
5.8
作者：
GLAUBER, HS;VOLLMER, WM;ORWOLL, ES
通讯作者：
ORWOLL, ES
影响因子：
7.1
作者：
MAZESS, RB;BARDEN, HS;HANSON, J
通讯作者：
HANSON, J
DOI：
10.1038/oby.2005.42
发表时间：
2005-02-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Hsu, FC;Lenchik, L;Carr, JJ
通讯作者：
Carr, JJ
影响因子：
6.2
作者：
MacInnis, RJ;Cassar, C;Wark, JD
通讯作者：
Wark, JD