Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders.
Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders.
复制标题
自闭症谱系障碍中杏仁核对情绪面孔的反应与社交焦虑之间的关联。
DOI：
10.1016/j.neuropsychologia.2010.07.022
复制
发表时间：
2010-10
期刊：
影响因子：
2.6
通讯作者：
Aylward E
中科院分区：
文献类型：
--
作者：
Kleinhans NM;Richards T;Weaver K;Johnson LC;Greenson J;Dawson G;Aylward E
据报道，自闭症谱系障碍（ASD）中存在难以解释面部表情的情况，并被认为与杏仁核异常有关。为了进一步探讨ASD患者异常情绪面孔加工的神经基础，我们对高功能ASD成年人和年龄、智商和性别匹配的对照组进行了情绪面孔匹配的fMRI研究。此外，我们还调查了自我报告的社交焦虑与功能磁共振成像激活之间是否存在关系。在功能磁共振成像扫描过程中，研究参与者被指示匹配描绘恐惧或愤怒的面部表情。控制条件是一个类似的形状匹配任务。对照组证明显着增加左前额叶激活和减少激活的枕叶相比，ASD组在情绪面部匹配。此外，在ASD组中，更大的社交焦虑与右侧杏仁核和左侧颞中回的激活增加以及梭状面区的激活减少相关。这些结果表明，社交焦虑水平介导的神经反应的情绪面孔知觉的ASD。
Difficulty interpreting facial expressions has been reported in autism spectrum disorders (ASD) and is thought to be associated with amygdala abnormalities. To further explore the neural basis of abnormal emotional face processing in ASD, we conducted an fMRI study of emotional face matching in high-functioning adults with ASD and age, IQ, and gender matched controls. In addition, we investigated whether there was a relationship between self-reported social anxiety and fMRI activation. During fMRI scanning, study participants were instructed to match facial expressions depicting fear or anger. The control condition was a comparable shape - matching task. The control group evidenced significantly increased left prefrontal activation and decreased activation in the occipital lobes compared to the ASD group during emotional face matching. Further, within the ASD group, greater social anxiety was associated with increased activation in right amygdala and left middle temporal gyrus, and decreased activation in the fusiform face area. These results indicate that level of social anxiety mediates the neural response to emotional face perception in ASD.
登录
查看更多内容
影响因子：
--
作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
9.9
作者：
Casanova, MF;Buxhoeveden, DP;Roy, E
通讯作者：
Roy, E
影响因子：
9.9
作者：
Hubl, D;Bölte, S;Dierks, T
通讯作者：
Dierks, T
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M
影响因子：
17.7
作者：
Kleinhans, Natalia M.;Johnson, L. Clark;Aylward, Elizabeth
通讯作者：
Aylward, Elizabeth