Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR-ERK Signaling Pathway.
Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR-ERK Signaling Pathway.
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柑橘sudachi果皮提取物通过抑制EGFR-ERK信号传导途径抑制细胞增殖并促进角质形成细胞的分化。
DOI：
10.3390/biom10101468
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发表时间：
2020-10-21
期刊：
影响因子：
5.5
通讯作者：
Yuasa K
中科院分区：
文献类型：
--
作者：
Abe S;Ueno M;Nishitani M;Akamatsu T;Sato T;Shimoda M;Kanaoka H;Nii Y;Yamasaki H;Yuasa K
柑橘是日本德岛县的著名水果，其果皮富含植物化学物质，包括酚类化合物。虽然预期C.苏丹红果皮具有多种有益的生理活性，但对皮肤的影响尚未研究。本文报道了用水提取法提取红毛忍冬果皮水提物。sudachi抑制永生化人角质形成细胞系HaCaT和原代正常人表皮角质形成细胞的细胞增殖。C.结果表明，苏打香皮提取物可抑制表皮生长因子（EGF）诱导的EGF受体激活和肿瘤坏死因子（TNF）-α诱导的细胞外调节激酶（ERK）1/2激活，提示其抑制作用是通过抑制EGF受体（EGFR）及其下游分子发挥的。此外，C.苏地果皮增强钙诱导的角质形成细胞分化。这些结果表明，C. Sudachi peel可以对以表皮角质细胞过度增殖为特征的皮肤病，例如在银屑病和皮肤鳞状细胞癌中所见的那些皮肤病具有有益的效果。
Citrus sudachi is a well-known fruit in Tokushima Prefecture, Japan, and its peels are rich in phytochemicals, including phenolic compounds. Although it is expected that the extract of the C. sudachi peel elicits various beneficial physiological activities, the effect on the skin has not been investigated. In this study, we report that the aqueous extract from the peel of C. sudachi suppresses cell proliferation of the immortalized human keratinocyte cell line, HaCaT, and primary normal human epidermal keratinocytes. The extract of C. sudachi peel suppressed epidermal growth factor (EGF)-induced EGF receptor activation and tumor necrosis factor (TNF)-α-induced extracellular regulated kinase (ERK) 1/2 activation, which suggests that the extract exerts its inhibitory effect through inhibition of both the EGF receptor (EGFR) and its downstream molecules. Additionally, the extract of C. sudachi peel potentiated calcium-induced keratinocyte differentiation. These results suggest that the extract of C. sudachi peel may have beneficial effects against skin diseases that are characterized by hyperproliferation of epidermal keratinocytes, such as those seen in psoriasis and in cutaneous squamous cell carcinoma.
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影响因子：
21.3
作者：
Kolev, Vihren;Mandinova, Anna;Guinea-Viniegra, Juan;Hu, Bing;Lefort, Karine;Lambertini, Chiara;Neel, Victor;Dummer, Reinhard;Wagner, Erwin F.;Dotto, G. Paolo
通讯作者：
Dotto, G. Paolo
柚皮素通过抑制 MAPKs-AP-1 和 IKKs-IκB-NF-κB 信号通路的合作活动，减少 EGF 诱导的 A549 细胞 MUC5AC 分泌
影响因子：
5
作者：
Nie, Yi-chu;Wu, Hao;Su, Wei-wei
通讯作者：
Su, Wei-wei
DOI：
10.1038/jid.2008.265
发表时间：
2009-03
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1038/nrc.2017.79
发表时间：
2017-11
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Karoulia Z;Gavathiotis E;Poulikakos PI
通讯作者：
Poulikakos PI
影响因子：
5.1
作者：
Nakagawa, Hiroyuki;Takaishi, Yoshihisa;Higuti, Tomihiko
通讯作者：
Higuti, Tomihiko