Effects of intravenous nicotine on prepulse inhibition in smokers and non-smokers: relationship with familial smoking.
Effects of intravenous nicotine on prepulse inhibition in smokers and non-smokers: relationship with familial smoking.
复制标题
DOI：
10.1007/s00213-013-3107-8
复制
发表时间：
2013-09
影响因子：
3.4
通讯作者：
Malcolm, Robert J.
中科院分区：
文献类型：
--
作者：
Drobes, David J.;MacQueen, David A.;Blank, Melissa D.;Saladin, Michael E.;Malcolm, Robert J.
尼古丁的增强特性可能部分源自其增强某些形式的认知处理的能力。多项动物和人类研究表明，尼古丁会增加惊吓反射的前脉冲抑制（PPI）。然而，目前尚不清楚这些影响是否与吸烟易感性有关。目前的研究调查了静脉注射尼古丁对吸烟者和非吸烟者 PPI 的影响，及其与家族吸烟定量指数的关系。样本由 30 名非吸烟者和 16 名吸烟者组成，他们完成了初步评估，随后在两次静脉注射尼古丁之前和之后的另一天进行了 PPI 实验室评估。吸烟者和非吸烟者样本中使用了不同的剂量。分析表明，两种尼古丁输注均显着增强非吸烟者的 PPI，并且这种增强与一级和二级亲属的吸烟程度呈正相关。吸烟者在接受第一次输注后也表现出 PPI 增强，但这种效应与家族吸烟无关。这些数据表明，PPI 范式可能可作为导致吸烟风险的认知过程的内表型。
The reinforcing properties of nicotine may be, in part, derived from its ability to enhance certain forms of cognitive processing. Several animal and human studies have shown that nicotine increases prepulse inhibition (PPI) of the startle reflex. However, it remains unclear whether these effects are related to smoking susceptibility. The current study examined the effects of intravenously delivered nicotine on PPI in smokers and nonsmokers, as well as its association with a quantitative index of familial smoking. The sample consisted of 30 non-smokers and 16 smokers, who completed an initial assessment, followed on a separate day by a laboratory assessment of PPI prior to and following each of two intravenous nicotine infusions. Separate doses were used in smoker and non-smoker samples. Analyses indicated that both nicotine infusions acutely enhanced PPI among non-smokers, and this enhancement was positively related to the degree of smoking among first and second-degree relatives. Smokers also displayed PPI enhancement after receiving the first infusion, but this effect was unrelated to familial smoking. These data suggest that the PPI paradigm may have utility as an endophenotype for cognitive processes which contribute to smoking risk.
登录
查看更多内容
影响因子：
3.4
作者：
ACRI, JB;MORSE, DE;GRUNBERG, NE
通讯作者：
GRUNBERG, NE
影响因子：
3.6
作者：
CURZON, P;KIM, DJB;DECKER, MW
通讯作者：
DECKER, MW
影响因子：
3.4
作者：
Baschnagel, Joseph S.;Hawk, Larry W., Jr.
通讯作者：
Hawk, Larry W., Jr.
影响因子：
--
作者：
BECK, AT;ERBAUGH, J;MENDELSOHN, M
通讯作者：
MENDELSOHN, M
影响因子：
3.4
作者：
Della Casa, V;Höfer, I;Feldon, J
通讯作者：
Feldon, J