Distinctive cutaneous and systemic features associated with antitranscriptional intermediary factor-1γ antibodies in adults with dermatomyositis.
Distinctive cutaneous and systemic features associated with antitranscriptional intermediary factor-1γ antibodies in adults with dermatomyositis.
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DOI：
10.1016/j.jaad.2014.12.009
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发表时间：
2015-03
影响因子：
13.8
通讯作者：
Casciola-Rosen, Livia
中科院分区：
文献类型：
--
作者：
Fiorentino, David F.;Kuo, Karen;Chung, Lorinda;Zaba, Lisa;Li, Shufeng;Casciola-Rosen, Livia
关键词：
针对转录中介因子(TIF)-1γ的抗体与皮肌炎（DM）的恶性肿瘤有关。鉴别糖尿病患者中与抗tif -1γ抗体相关的临床表现是患者诊断和风险评估的重中之重。我们试图确定抗tifi -1γ糖尿病患者的临床表型。使用一种新的、敏感的、特异性的抗tifi -1γ抗体检测方法，我们回顾性检测了134名成年糖尿病患者的血浆，并检查了抗tifi -1γ抗体与特定临床和实验室特征之间的关系。总共有55例（41%）患者有TIF-1γ自身抗体。Anti-TIF-1γ阳性患者不太可能出现系统性特征，包括间质性肺疾病、雷诺现象和关节炎/关节痛。携带TIF-1γ自身抗体的患者有更广泛的皮肤受累，一些患者表现出特征性的发现，包括手掌角化性丘疹、牛皮癣样病变和新发现的色素减退和毛细血管扩张（“红白相间”）斑块。这是一项来自单一三级转诊中心的回顾性研究。在美国的一个大型队列中，TIF-1γ是成人中最常见的dm特异性自身抗原。虽然这些患者往往没有全身性受累，但他们的皮肤病往往是广泛和特征性的。识别抗tif -1γ阳性患者的皮肤表现可以更准确、及时地诊断和有效地治疗糖尿病患者。
Antibodies against transcriptional intermediary factor (TIF)-1γ are associated with malignancy in dermatomyositis (DM). Identification of clinical findings associated with anti-TIF-1γ antibodies in DM is a high priority for both patient diagnosis and risk assessment. We sought to define the clinical phenotype of patients with anti-TIF-1γ DM. Using a novel, sensitive, and specific assay for anti-TIF-1γ antibodies, we retrospectively tested plasma from 134 adult patients with DM and examined associations between anti-TIF-1γ antibodies and particular clinical and laboratory features. In all, 55 (41%) patients had autoantibodies to TIF-1γ. Anti-TIF-1γ positive patients were less likely to have systemic features including interstitial lung disease, Raynaud phenomenon, and arthritis/arthralgia. Patients with TIF-1γ autoantibodies had more extensive skin involvement, and some patients manifested characteristic findings including palmar hyperkeratotic papules, psoriasis-like lesions and a novel finding of hypopigmented and telangiectatic (“red on white”) patches. This was a retrospective study from a single tertiary referral center. TIF-1γ is the most commonly targeted DM-specific autoantigen in adults in a large US cohort. Although these patients tend to have less systemic involvement, their skin disease is often extensive and characteristic. Recognition of cutaneous findings in anti-TIF-1γ positive patients may allow more accurate and timely diagnosis and effective treatment of patients with DM.
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DOI：
10.1111/j.1365-2133.2009.09521.x
发表时间：
2010-03
期刊：
The British journal of dermatology
影响因子：
--
作者：
Yassaee M;Fiorentino D;Okawa J;Taylor L;Coley C;Troxel AB;Werth VP
通讯作者：
Werth VP
影响因子：
2.2
作者：
Kang, Eun Ha;Kuwana, Masataka;Song, Yeong Wook
通讯作者：
Song, Yeong Wook
影响因子：
2.3
作者：
Kang EH;Nakashima R;Mimori T;Kim J;Lee YJ;Lee EB;Song YW
通讯作者：
Song YW
影响因子：
5.5
作者：
Kaji, K.;Fujimoto, M.;Takehara, K.
通讯作者：
Takehara, K.
影响因子：
10.9
作者：
Valenzuela, Antonia;Chung, Lorinda;Casciola-Rosen, Livia;Fiorentino, David
通讯作者：
Fiorentino, David