Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation.
Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation.
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DOI：
10.3390/v14040684
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发表时间：
2022-03-25
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影响因子：
--
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最近对波长在200-235纳米范围内的紫外线辐射（通常称为远紫外线）进行的研究表明，与这些波长有关的健康危害最小，可以在有人居住的室内空间内直接使用远紫外线辐射，以提供持续消毒。早期的实验研究基于拟合指数剂量反应曲线来估计暴露于222纳米辐射下空气传播的人类冠状病毒OC43的易感性。目前的研究将结果扩展到222 nm远紫外线辐射的更大剂量范围，并使用耦合辐射输运和计算流体动力学的计算模型来改进剂量学估计。新的结果表明，在我们的暴露系统中，用双指数剂量-反应关系更好地描述了人类冠状病毒OC43的失活，估计的低剂量敏感性常数（实际低剂量率暴露的相关参数）为12.4±0.4 cm2/mJ，描述了99.7%±0.05%的病毒群体的行为。这一新估计值是早先基于单指数剂量反应的敏感性常数估计值的两倍多。这些新结果为远紫外线灭活空气传播病原体的功效提供了进一步的证据。
Recent research using UV radiation with wavelengths in the 200–235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier experimental studies estimated the susceptibility of airborne human coronavirus OC43 exposed to 222-nm radiation based on fitting an exponential dose–response curve to the data. The current study extends the results to a wider range of doses of 222 nm far-UVC radiation and uses a computational model coupling radiation transport and computational fluid dynamics to improve dosimetry estimates. The new results suggest that the inactivation of human coronavirus OC43 within our exposure system is better described using a bi-exponential dose–response relation, and the estimated susceptibility constant at low doses—the relevant parameter for realistic low dose rate exposures—was 12.4 ± 0.4 cm2/mJ, which described the behavior of 99.7% ± 0.05% of the virus population. This new estimate is more than double the earlier susceptibility constant estimates that were based on a single-exponential dose response. These new results offer further evidence as to the efficacy of far-UVC to inactivate airborne pathogens.
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