Sex hormone influence on female-biased autoimmune diseases hints at puberty as an important factor in pathogenesis.
Sex hormone influence on female-biased autoimmune diseases hints at puberty as an important factor in pathogenesis.
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DOI：
10.3389/fped.2023.1051624
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发表时间：
2023
影响因子：
2.6
通讯作者：
Liang, Yun
中科院分区：
文献类型：
--
作者：
Yang, Qianfan;Kennicott, Kameron;Zhu, Runqi;Kim, Jooyong;Wakefield, Hunter;Studener, Katelyn;Liang, Yun
大多数自身免疫性疾病对女性的影响多于男性，这表明性激素在调节免疫反应中发挥着重要作用。目前的研究支持这一观点，强调了性激素在免疫和代谢调节中的重要性。青春期的特点是性激素水平和新陈代谢的急剧变化。这些青春期的变化可能是造成男性和女性之间对自身免疫的性别偏见的鸿沟的原因。在这篇综述中，提出了关于青春期免疫代谢变化及其对一组选定的自身免疫性疾病发病机制的影响的当前观点。本次综述重点关注 SLE、RA、JIA、SS 和 ATD，因为它们具有显着的性别偏见和患病率。由于青春期自身免疫数据的缺乏以及青少年类似物的机制或发病年龄的差异通常在青春期变化之前开始，因此有关特定成人自身免疫性疾病与青春期之间联系的数据通常依赖于性激素对发病机制的影响，并确定了青春期开始的免疫方面的性别差异。
The majority of autoimmune diseases affect more women than men, suggesting an important role for sex hormones in regulating immune response. Current research supports this idea, highlighting the importance of sex hormones in both immune and metabolic regulation. Puberty is characterized by drastic changes in sex hormone levels and metabolism. These pubertal changes may be what forms the gulf between men and women in sex bias towards autoimmunity. In this review, a current perspective on pubertal immunometabolic changes and their impact on the pathogenesis of a select group of autoimmune diseases is presented. SLE, RA, JIA, SS, and ATD were focused on in this review for their notable sex bias and prevalence. Due to both the scarcity of pubertal autoimmune data and the differences in mechanism or age-of-onset in juvenile analogues often beginning prior to pubertal changes, data on the connection between the specific adult autoimmune diseases and puberty often relies on sex hormone influence in pathogenesis and established sex differences in immunity that begin during puberty.
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DOI：
10.1097/00075197-200111000-00006
发表时间：
2001-11-01
影响因子：
3.1
作者：
Blaak, E
通讯作者：
Blaak, E
影响因子：
3.4
作者：
Bunoti, Sarah Nantono;Tumwesigye, Nazarius Mbona;Atuyambe, Lynn
通讯作者：
Atuyambe, Lynn
影响因子：
7.2
作者：
Coussens, Lisa M.;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.
影响因子：
4.1
作者：
Blais, Y;Gingras, S;Simard, J
通讯作者：
Simard, J
影响因子：
3.6
作者：
Gadkar, S;Shah, CA;Puri, CP
通讯作者：
Puri, CP