Race and sex differences in cardiovascular autonomic regulation.
Race and sex differences in cardiovascular autonomic regulation.
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DOI：
10.1007/s10286-020-00723-z
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Shibao CA
中科院分区：
文献类型：
--
作者：
Farrell MC;Giza RJ;Shibao CA
尽管在危险因素识别和循证治疗策略的实施方面取得了进展，但心血管疾病发病率和死亡率的种族和民族差异仍然存在。非裔美国人男性和女性不成比例地受到心血管风险因素的影响，特别是高血压。在这种情况下，以前的研究已经确定了自主心血管调节的性别和种族差异，这可能有助于高血压的发展和非洲裔美国人的高发病率负担。在这篇综述中，我们提供了一个全面的评估血压控制的潜在病理生理机制及其性别和种族的差异。这些机制包括肥胖诱导的交感神经激活、交感神经-血管转导、压力反射敏感性和肾上腺素受体血管敏感性，这些都是该领域先前研究的主题。了解高血压病理生理学的种族差异及其共病状况将使我们能够实施更好的针对非裔美国人的治疗策略，最终目标是降低这一人群的心血管死亡率。
Racial and ethnic differences in cardiovascular morbidity and mortality persist despite advances in risk factor identification and implementation of evidence-based treatment strategies. African American men and women are disproportionately affected by cardiovascular risk factors, particularly hypertension. In this context, previous studies have identified sex and racial differences in autonomic cardiovascular regulation which may contribute to the development of hypertension and its high morbidity burden among African Americans. In this review, we provide a comprehensive evaluation of the potential pathophysiological mechanisms of blood pressure control and their differences based on sex and race. These mechanisms include obesity-induced sympathetic activation, sympatho-vascular transduction, baroreflex sensitivity and adrenoreceptor vascular sensitivity, which have been the subjects of prior investigation in this field. Understanding the racial differences in the pathophysiology of hypertension and its co-morbid conditions would allow us to implement better treatment strategies tailored to African Americans, with the ultimate goal of reducing cardiovascular mortality in this population.
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影响因子：
--
作者：
Cygankiewicz, Iwona;Zareba, Wojciech
通讯作者：
Zareba, Wojciech
DOI：
10.1152/ajpheart.00387.2018
发表时间：
2018-11-01
影响因子：
4.8
作者：
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通讯作者：
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影响因子：
37.8
作者：
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通讯作者：
Davy, KP
DOI：
10.3109/10641968909045414
发表时间：
1989-01-01
期刊：
CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE
影响因子：
--
作者：
ESLER, M;LAMBERT, G;JENNINGS, G
通讯作者：
JENNINGS, G
影响因子：
6.9
作者：
Graziano, Paulo A.;Calkins, Susan D.;Keane, Susan P.;O'Brien, Marion
通讯作者：
O'Brien, Marion