Liter-scale production of uniform gas bubbles via parallelization of flow-focusing generators.
Liter-scale production of uniform gas bubbles via parallelization of flow-focusing generators.
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DOI：
10.1039/c7lc00295e
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发表时间：
2017-07-25
期刊：
影响因子：
6.1
通讯作者：
Lee D
中科院分区：
文献类型：
--
作者：
Jeong HH;Yadavali S;Issadore D;Lee D
微型气泡作为合成医学功能材料、超轻材料和声学超材料的通用模板已展现出巨大的实用性。在许多此类应用中，气泡尺寸的高度均匀性对于实现所需的性能和功能至关重要。虽然微流体已成功地用于产生具有使用传统方法无法实现的均匀性的气泡，但微流体固有的低体积流速限制了其在大多数应用中的使用。液滴发生器的并行化（其中许多液滴发生器被集成到单个芯片上）已经显示出大规模生产单分散液体乳液液滴的巨大前景。然而，由于平行气泡发生器和下游通道的反馈效应之间可能存在耦合，使用这种方法放大单分散气泡仍然是一个挑战。在本报告中，我们系统地研究了连续相粘度、毛细管数、气压以及通道均匀性等因素对并行微流控装置中气泡尺寸分布的影响。我们表明，通过优化流动条件，在 5 × 5 cm2 占地面积上配备 400 个平行流聚焦发生器的装置可用于以大约 1 L/hr 的生产率产生变异系数小于 5% 的气泡。我们的结果表明，使用具有少量（例如 8 个）并行 FFG 的设备优化流动条件可以促进大规模气泡产生。并行微流体装置用于以 ~ 1 L/hr 的生产率产生高度单分散的气泡。
Microscale gas bubbles have demonstrated enormous utility as versatile templates for the synthesis of functional materials in medicine, ultra-lightweight materials and acoustic metamaterials. In many of these applications, high uniformity of the size of the gas bubbles is critical to achieve the desired properties and functionality. While microfluidics have been used with success to create gas bubbles that have a uniformity not achievable using conventional methods, the inherently low volumetric flow rate of microfluidics has limited its use in most applications. Parallelization of liquid droplet generators, in which many droplet generators are incorporated onto a single chip, has shown great promise for the large scale production of monodisperse liquid emulsion droplets. However, the scale-up of monodisperse gas bubbles using such an approach has remained a challenge because of possible coupling between parallel bubbles generators and feedback effects from the downstream channels. In this report, we systematically investigate the effect of factors such as viscosity of the continuous phase, Capillary number, and gas pressure as well as the channel uniformity on the size distribution of gas bubbles in a parallelized microfluidic device. We show that, by optimizing the flow conditions, a device with 400 parallel flow focusing generators on a footprint of 5 × 5 cm2 can be used to generate gas bubbles with a coefficient of variation of less than 5% at a production rate of approximately 1 L/hr. Our results suggest that the optimization of flow conditions using a device with a small number (e.g., 8) of parallel FFGs can facilitate large-scale bubble production. A parallelized microfluidic device is used to generate highly monodisperse gas bubbles at a production rate of ~ 1 L/hr.
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