A novel microneedle array for the treatment of hydrocephalus.
A novel microneedle array for the treatment of hydrocephalus.
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DOI：
10.1007/s00542-013-1988-4
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发表时间：
2014-06-01
影响因子：
2.1
通讯作者：
Noh, Hongseok (Moses)
中科院分区：
文献类型：
--
作者：
Oh, Jonghyun;Liu, Kewei;Medina, Tim;Kralick, Francis;Noh, Hongseok (Moses)
我们提出了一种微制造的10 × 10微针阵列，用于治疗一种称为交通性脑积水的神经系统疾病。与先前报道的微阀阵列一起，当前的可植入微针阵列完成了模拟正常蛛网膜颗粒（AG）功能的微制造蛛网膜颗粒（MAG）。微针阵列被设计成能够通过脑中的硬脑膜固定MAG，从而为脑脊液（CSF）的流动提供管道。采用SU-8光刻法、反应离子刻蚀法、248 nm深紫外准分子激光加工法和金属溅射法制备了具有中空通道的锥形微针。使用猪硬脑膜进行穿刺测试，结果显示所制造的微针阵列足够坚固以刺穿硬脑膜。体外生物相容性测试结果显示，暴露于血流的100个微针出口中没有一个被血细胞显著堵塞。我们认为，这些测试结果证明了微针阵列作为脑积水新治疗方法的潜在用途。
We present a microfabricated 10 by 10 array of microneedles for the treatment of a neurological disease called communicating hydrocephalus. Together with the previously reported microvalve array, the current implantable microneedle array completes the microfabricated arachnoid granulations (MAGs) that mimic the function of normal arachnoid granulations (AGs). The microneedle array was designed to enable the fixation of the MAGs through dura mater membrane in the brain and thus provide a conduit for the flow of cerebrospinal fluid (CSF). Cone-shaped microneedles with hollow channels were fabricated using a series of microfabrication techniques: SU-8 photolithography for tapered geometry, reactive ion etching for sharpening the microneedles, 248 nm deep UV excimer laser machining for creating through-hole inside the microneedles, and metal sputtering for improved rigidity. Puncture tests were conducted using porcine dura mater and the results showed that the fabricated microneedle array is strong enough to pierce the dura mater. The in-vitro biocompatibility test result showed that none of the 100 outlets of the microneedles exposed to the bloodstream were clogged significantly by blood cells. We believe that these test results demonstrate the potential use of the microneedle array as a new treatment of hydrocephalus.
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DOI：
10.1088/0960-1317/22/1/015012
发表时间：
2012-01-01
影响因子：
2.3
作者：
Liu, Kewei;NiCkolov, Zhorro;Noh, Hongseok Moses
通讯作者：
Noh, Hongseok Moses
影响因子：
3.2
作者：
Choudhury, Deepak;Mo, Xuejun;Yu, Hanry
通讯作者：
Yu, Hanry
影响因子：
2.7
作者：
Oh, Jonghyun;Kim, Gyuman;Noh, Hongseok
通讯作者：
Noh, Hongseok
影响因子：
4.8
作者：
Patwardhan, RV;Nanda, A
通讯作者：
Nanda, A
影响因子：
2.8
作者：
Choi, Yoonsu;McClain, Maxine A.;Allen, Mark G.
通讯作者：
Allen, Mark G.