Role of Intestinal Microbes in Chronic Liver Diseases.
Role of Intestinal Microbes in Chronic Liver Diseases.
复制标题
肠道微生物在慢性肝病中的作用
DOI：
10.3390/ijms232012661
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发表时间：
2022-10-21
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
随着近年来许多新兴肠道微生物测序技术的出现和升级，我们对肠道微生物的研究正在迅速发生变化。各种研究发现肠道微生物对于免疫系统调节和能量代谢稳态至关重要，这会影响许多关键器官。肝脏是肠道门静脉所经过的第一个器官，肝脏与肠道之间有很强的双向联系。许多肠道因素，如肠道微生物、细菌组成和肠道细菌代谢产物，与肝脏稳态密切相关。肠道微生物失调和肠道通透性增加与许多慢性肝病的发病机制有关，例如酒精性脂肪肝病（AFLD）、非酒精性脂肪肝病（NAFLD）、非酒精性脂肪性肝炎（NASH）、慢性乙型肝炎（CHB）、慢性丙型肝炎（CHC）、自身免疫性肝病（AIH）和肝细胞癌（HCC）的发展。肠道通透性和菌群失调常常导致脂多糖（LPS）和代谢物进入血清。然后，肝脏中 Toll 样受体的激活导致肠道和肝脏暴露于许多具有促炎特性的小分子。所有这些最终都会导致各种肝脏疾病。在本文中，我们讨论了各种肠道微生物在不同慢性肝病中作用的现有证据。本综述还提出了潜在的新治疗方法，例如抗生素、益生菌和益生元，它们可能对肝脏疾病有改善作用。
With the recent availability and upgrading of many emerging intestinal microbes sequencing technologies, our research on intestinal microbes is changing rapidly. A variety of investigations have found that intestinal microbes are essential for immune system regulation and energy metabolism homeostasis, which impacts many critical organs. The liver is the first organ to be traversed by the intestinal portal vein, and there is a strong bidirectional link between the liver and intestine. Many intestinal factors, such as intestinal microbes, bacterial composition, and intestinal bacterial metabolites, are deeply involved in liver homeostasis. Intestinal microbial dysbiosis and increased intestinal permeability are associated with the pathogenesis of many chronic liver diseases, such as alcoholic fatty liver disease (AFLD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), chronic hepatitis B (CHB), chronic hepatitis C (CHC), autoimmune liver disease (AIH) and the development of hepatocellular carcinoma (HCC). Intestinal permeability and dysbacteriosis often lead to Lipopolysaccharide (LPS) and metabolites entering in serum. Then, Toll-like receptors activation in the liver induces the exposure of the intestine and liver to many small molecules with pro-inflammatory properties. And all of these eventually result in various liver diseases. In this paper, we have discussed the current evidence on the role of various intestinal microbes in different chronic liver diseases. As well as potential new therapeutic approaches are proposed in this review, such as antibiotics, probiotics, and prebiotics, which may have an improvement in liver diseases.
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影响因子：
24.5
作者：
Cani PD
通讯作者：
Cani PD
影响因子：
15.5
作者：
De Vrieze J;Pinto AJ;Sloan WT;Ijaz UZ
通讯作者：
Ijaz UZ
影响因子：
2.4
作者：
Chang B;Sang L;Wang Y;Tong J;Zhang D;Wang B
通讯作者：
Wang B
DOI：
10.1038/s41579-021-00621-9
发表时间：
2022-03
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
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影响因子：
9.8
作者：
Buzzetti, Elena;Pinzani, Massimo;Tsochatzis, Emmanuel A.
通讯作者：
Tsochatzis, Emmanuel A.