Long-term and baseline recreational physical activity and risk of endometrial cancer: the California Teachers Study.
Long-term and baseline recreational physical activity and risk of endometrial cancer: the California Teachers Study.
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DOI：
10.1038/bjc.2013.61
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发表时间：
2013-08-06
影响因子：
8.8
通讯作者：
Bernstein, L.
中科院分区：
文献类型：
--
作者：
Dieli-Conwright, C. M.;Ma, H.;Lacey, J. V., Jr.;Henderson, K. D.;Neuhausen, S.;Horn-Ross, P. L.;Deapen, D.;Sullivan-Halley, J.;Bernstein, L.
体力活动可能与降低子宫内膜癌风险有关；目前尚不清楚这种联系是否会被体型改变。在93名符合 888标准的加州教师研究参与者中，976人在1995年至1996年至2007年期间被诊断为子宫内膜癌。使用COX比例风险回归方法估计子宫内膜癌与长期(高中至54岁)和基线(加入队列前3年)剧烈和中度娱乐性体力活动有关的相对危险度(RR)和95%可信区间(CI)，总体上和按身体大小进行。每周锻炼3 h的女性患子宫内膜癌的风险比每周锻炼1/2 h的女性低约25%(RR，0.76；95%CI，0.63-0.92)，与基线剧烈的娱乐性体力活动与降低子宫内膜癌风险相关(P趋势=0.006)。在超重/肥胖女性中观察到了这种相反的关联(身体质量指数≥25 kg m−2；P趋势=0.006)，但在较瘦的女性中没有观察到(P趋势=0.12)。在超重/肥胖女性中，适度的基线活动与较低的风险相关。增加体力活动，特别是剧烈运动，可能是一种生活方式的改变，超重和肥胖的女性可以通过这种改变来降低她们患子宫内膜癌的风险。
Physical activity may be associated with decreasing endometrial cancer risk; it remains unclear whether the association is modified by body size. Among 93 888 eligible California Teachers Study participants, 976 were diagnosed with incident endometrial cancer between 1995–1996 and 2007. Cox proportional hazards regression methods were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for endometrial cancer associated with long-term (high school through age 54 years) and baseline (3 years prior to joining the cohort) strenuous and moderate recreational physical activity, overall and by body size. Increased baseline strenuous recreational physical activity was associated with decreased endometrial cancer risk (Ptrend=0.006) with approximately 25% lower risk among women exercising >3 h per week per year than among those exercising <1/2 h per week per year (RR, 0.76; 95% CI, 0.63–0.92). This inverse association was observed among overweight/obese women (body mass index ≥25 kg m−2; Ptrend=0.006), but not among thinner women (Ptrend=0.12). Baseline moderate activity was associated with lower risk among overweight/obese women. Increasing physical activity, particularly strenuous activity, may be a lifestyle change that overweight and obese women can implement to reduce their endometrial cancer risk.
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影响因子：
2.3
作者：
Conroy, Molly B.;Sattelmair, Jacob R.;Cook, Nancy R.;Manson, JoAnn E.;Buring, Julie E.;Lee, I-Min
通讯作者：
Lee, I-Min
影响因子：
6.4
作者：
Lukanova, A;Zeleniuch-Jacquotte, A;Kaaks, R
通讯作者：
Kaaks, R
影响因子：
5
作者：
CAULEY, JA;GUTAI, JP;POWELL, JG
通讯作者：
POWELL, JG
影响因子：
5
作者：
Littman, AJ;Voigt, LF;Weiss, NS
通讯作者：
Weiss, NS
DOI：
10.1038/oby.2002.140
发表时间：
2002-10-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Irwin, ML;Ainsworth, BE;Durstine, JL
通讯作者：
Durstine, JL