Hebbian and homeostatic plasticity mechanisms are segregated in sub-types of layer 5 neuron in the visual cortex
Hebbian and homeostatic plasticity mechanisms are segregated in sub-types of layer 5 neuron in the visual cortex
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赫布可塑性机制和稳态可塑性机制在视觉皮层第 5 层神经元的亚型中是分离的
DOI：
10.1101/2022.02.11.480060
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Pandey A
中科院分区：
文献类型：
--
作者：
Pandey A
皮质层 5 包含两种主要类型的投射神经元，称为在皮质下投射的 IB（内在爆发）细胞和在皮质区域之间投射的 RS（规则尖峰）细胞。我们研究了小鼠眼优势可塑性关键时期视觉皮层 RS 和 IB 细胞的可塑性特性。 RS 神经元对黑暗暴露 (DE) 和单眼剥夺 (MD) 均表现出突触抑制，并且它们从抑制中恢复的稳态恢复依赖于 TNFα。相反，IB细胞对DE和MD表现出相反的反应，对DE增强而对MD抑制。 IB 细胞的增强取决于 CaMKII 自磷酸化，而不是 TNFα。 IB细胞在关键期开始时表现出成熟的突触特性，而RS细胞在关键期期间成熟。结合体感皮层的观察结果，这些结果表明 RS 和 IB 可塑性机制的差异是一种普遍的皮层特性。意义陈述新皮层包含投射到大脑不同位置的细胞。在这项研究中，我们表明投射到不同目标位置的神经元表现出不同的突触可塑性机制。皮质投射细胞显示突触抑制和稳态上调，皮质下投射细胞显示经典赫布增强。这很重要，因为它意味着皮层神经元对经验的反应和编码信息的方式取决于它所嵌入的神经元子电路。我们表明，忽视这种区别会导致关于可塑性时间进程和意义的错误结论。这些发现为理解学习和记忆在大脑皮层的子回路中如何组织迈出了重要的一步。
Cortical layer 5 contains two major types of projection neuron known as IB (intrinsic bursting) cells that project sub-cortically and RS (regular spiking) cells that project between cortical areas. We studied the plasticity properties of RS and IB cells in the visual cortex during the critical period for ocular dominance plasticity in mice. RS neurons exhibited synaptic depression in response to both dark exposure (DE) and monocular deprivation (MD), and their homeostatic recovery from depression was dependent on TNFα. In contrast, IB cells demonstrated opposite responses to DE and MD, potentiating to DE and depressing to MD. IB cells’ potentiation depended on CaMKII-autophosphorylation and not TNFα. IB cells showed mature synaptic properties at the start of the critical period while RS cells matured during the critical period. Together with observations in somatosensory cortex, these results suggest that differences in RS and IB plasticity mechanisms are a general cortical property.Significance StatementThe neocortex contains cells that project to different locations in the brain. In this study we show that neurons projecting to different target locations exhibit different synaptic plasticity mechanisms. Cortically projecting cells show synaptic depression and homeostatic up-regulation, subcortically projecting cells show classical Hebbian potentiation. This is important because it implies that the way a cortical neuron responds to experience and encodes information depends on the neuronal subcircuits in which it is embedded. We show that ignoring this distinction leads to erroneous conclusions regarding plasticity time-course and significance. These findings constitute an important step toward understanding how learning and memory is organized within subcircuits in the cerebral cortex.
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影响因子：
2.5
作者：
Hattox, Alexis M.;Nelson, Sacha B.
通讯作者：
Nelson, Sacha B.
DOI：
10.1146/annurev-cellbio-100814-125353
发表时间：
2015
影响因子：
11.3
作者：
Lodato S;Arlotta P
通讯作者：
Arlotta P
影响因子：
2.5
作者：
Daw, NW;Gordon, B;Czepita, D
通讯作者：
Czepita, D
DOI：
10.1016/0165-3806(89)90183-1
发表时间：
1989-06-01
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
GU, Q;BEAR, MF;SINGER, W
通讯作者：
SINGER, W
影响因子：
5.3
作者：
Medini, Paolo
通讯作者：
Medini, Paolo