Comparative study on the antioxidant and anti-Toxoplasma activities of vanillin and its resorcinarene derivative.
Comparative study on the antioxidant and anti-Toxoplasma activities of vanillin and its resorcinarene derivative.
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DOI：
10.3390/molecules19055898
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发表时间：
2014-05-07
期刊：
影响因子：
--
通讯作者：
Andrade-Neto VF
中科院分区：
文献类型：
--
作者：
Oliveira CB;Meurer YS;Oliveira MG;Medeiros WM;Silva FO;Brito AC;Pontes Dde L;Andrade-Neto VF
合成了香草醛的间苯二酚芳烃衍生物resvan，并对其进行了光谱表征。我们测量了香草醛和间苯二酚芳烃化合物的细胞毒性（体内和体外）、抗氧化和抗弓形虫活性。在这里，我们通过体外细胞毒性试验表明香草醛具有剂量依赖性行为，IC 50为645 µg/mL。然而，我们在较高浓度的resvan（IC 50> 2，000 µg/mL）下未观察到任何细胞毒性反应。香草醛和白藜芦醇的体内急性毒性试验显示出显著的安全范围，这表明在给药后的前30分钟、24小时或14天内，高达300 mg/kg没有全身和行为毒性。当香草醛浓度为1,000 μg/mL时，所得衍生物的抗氧化活性（84.9%）高于香草醛（19.4%）。此外，香草醛具有抗弓形虫活性，而resvan不显示该特征。我们的研究结果表明，这种特殊的衍生物具有有效的抗氧化活性和可忽略的细胞毒性作用，使其成为进一步生物学研究的潜在目标。
A resorcinarene derivative of vanillin, resvan, was synthesized and characterized by spectroscopic techniques. We measured the cytotoxicity (in vivo and in vitro), antioxidant and anti-Toxoplasma activities of vanillin and the resorcinarene compound. Here we show that vanillin has a dose-dependent behavior with IC50 of 645 µg/mL through an in vitro cytotoxicity assay. However, we could not observe any cytotoxic response at higher concentrations of resvan (IC50 > 2,000 µg/mL). The in vivo acute toxicity assays of vanillin and resvan exhibited a significant safety margin indicated by a lack of systemic and behavioral toxicity up to 300 mg/kg during the first 30 min, 24 h or 14 days after administration. The obtained derivative showed greater antioxidative activity (84.9%) when comparing to vanillin (19.4%) at 1,000 μg/mL. In addition, vanillin presents anti-Toxoplasma activity, while resvan does not show that feature. Our findings suggest that this particular derivative has an efficient antioxidant activity and a negligible cytotoxic effect, making it a potential target for further biological investigations.
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影响因子：
6.6
作者：
Carruthers, Vern B.;Suzuki, Yasuhiro
通讯作者：
Suzuki, Yasuhiro
影响因子：
2.1
作者：
de Oliveira, Taisa Carrijo;Oliveira Silva, Deise A.;Mineo, Jose Roberto
通讯作者：
Mineo, Jose Roberto
影响因子：
5.4
作者：
Fitzgerald, DJ;Stratford, M;Narbad, A
通讯作者：
Narbad, A
DOI：
10.1590/s0074-02762002000400001
发表时间：
2002-06-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Ferreira, Marcelo Simão;Borges, Aércio Sebastião
通讯作者：
Borges, Aércio Sebastião
影响因子：
2.7
作者：
Degerli, K;Kilimcioglu, AA;Özbilgin, A
通讯作者：
Özbilgin, A