The gut microbiota and human health with an emphasis on the use of microencapsulated bacterial cells.
The gut microbiota and human health with an emphasis on the use of microencapsulated bacterial cells.
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DOI：
10.1155/2011/981214
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发表时间：
2011
影响因子：
--
通讯作者：
Cantor A
中科院分区：
文献类型：
--
作者：
Prakash S;Tomaro-Duchesneau C;Saha S;Cantor A
肠道微生物群在维持健康方面起着至关重要的作用。肠道细菌种群的改变与许多疾病有关。过去和最近的研究表明，人们可以通过引入益生元，益生菌，合生元和其他疗法来积极改变肠道微生物群的内容。本文重点介绍益生菌通过将其递送至下胃肠道（GIT）来调节肠道微生物群。在微生物可以用作治疗剂之前，有许多障碍需要克服。一个重要的限制是将活细胞递送至下GIT而不会通过上GIT的苛刻条件显著损失细胞活力和代谢特征。微胶囊化已被证明可以克服这一点，各种类型的微胶囊可用于解决这一限制。本文讨论了肠道微生物群及其在疾病中的作用，重点是微胶囊化益生菌及其潜力和局限性。
The gut microbiota plays a crucial role in maintaining health. Alterations of the gut bacterial population have been associated with a number of diseases. Past and recent studies suggest that one can positively modify the contents of the gut microbiota by introducing prebiotics, probiotics, synbiotics, and other therapeutics. This paper focuses on probiotic modulation of the gut microbiota by their delivery to the lower gastrointestinal tract (GIT). There are numerous obstacles to overcome before microorganisms can be utilized as therapeutics. One important limitation is the delivery of viable cells to the lower GIT without a significant loss of cell viability and metabolic features through the harsh conditions of the upper GIT. Microencapsulation has been shown to overcome this, with various types of microcapsules available for resolving this limitation. This paper discusses the gut microbiota and its role in disease, with a focus on microencapsulated probiotics and their potentials and limitations.
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