Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy.
Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy.
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金属有机框架涂层金纳米棒作为化学光热癌症治疗的按需药物输送平台
DOI：
10.1186/s12951-021-00961-x
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发表时间：
2021-07-19
影响因子：
10.2
通讯作者：
Yang C
中科院分区：
文献类型：
--
作者：
Huang J;Xu Z;Jiang Y;Law WC;Dong B;Zeng X;Ma M;Xu G;Zou J;Yang C
基于纳米粒子的化学-光热疗法已成为一种很有前途的癌症治疗策略。然而，其治疗效果和应用潜力在很大程度上受制于功能纳米平台的不可控性和生物毒性。为此，设计并制备了一种新型的生物相容性和生物可降解性金属有机骨架(MOF)，它是通过在金纳米载体(Au@ZIF-8)上生长结晶型分子筛咪唑骨架-8构建的，用于高效载药和控释。由于ZIF-8具有较大的比表面积和客体匹配的孔径，阿霉素被成功地负载到Au@ZIF-8中，载药率达到 ~ 的37%。在近红外光或弱酸性环境下，ZIF-8层被迅速降解，导致肿瘤部位的药物按需释放。更重要的是，在近红外(NIR)激光照射下，由于光热(PTT)治疗和化疗的协同作用，在体外细胞实验和体内荷瘤裸鼠实验中都实现了高效的肿瘤治疗。体内实验表明，Au@ZIF-8具有良好的生物相容性。这项工作有力地表明，Au@ZIF-8可以作为一种用于化学-光热协同治疗的药物释放系统进行进一步的探索。
Chemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy.
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DOI：
10.1056/nejmoa1804710
发表时间：
2018-07-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sparano JA;Gray RJ;Makower DF;Pritchard KI;Albain KS;Hayes DF;Geyer CE Jr;Dees EC;Goetz MP;Olson JA Jr;Lively T;Badve SS;Saphner TJ;Wagner LI;Whelan TJ;Ellis MJ;Paik S;Wood WC;Ravdin PM;Keane MM;Gomez Moreno HL;Reddy PS;Goggins TF;Mayer IA;Brufsky AM;Toppmeyer DL;Kaklamani VG;Berenberg JL;Abrams J;Sledge GW Jr
通讯作者：
Sledge GW Jr
临床试验装置研究中金纳米壳局部光热消融前列腺肿瘤
DOI：
10.1073/pnas.1906929116
发表时间：
2019-09-10
影响因子：
11.1
作者：
Rastinehad, Ardeshir R.;Anastos, Harry;Halas, Naomi J.
通讯作者：
Halas, Naomi J.
影响因子：
3.7
作者：
Ali, Moustafa R. K.;Wu, Yue;El-Sayed, Mostafa A.
通讯作者：
El-Sayed, Mostafa A.
DOI：
10.1016/j.msec.2018.06.002
发表时间：
2018-10-01
影响因子：
7.9
作者：
Encinas-Basurto, David;Ibarra, Jaime;Valdez, Miguel A.
通讯作者：
Valdez, Miguel A.
影响因子：
64.8
作者：
Vasan N;Baselga J;Hyman DM
通讯作者：
Hyman DM