Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies.
Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies.
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DOI：
10.2337/dc11-2055
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发表时间：
2012-05
期刊：
影响因子：
16.2
通讯作者：
Hu FB
中科院分区：
文献类型：
--
作者：
Pan A;Keum N;Okereke OI;Sun Q;Kivimaki M;Rubin RR;Hu FB
流行病学研究反复调查了抑郁症和代谢综合征（MetS）之间的关系。然而，结果却不一致。本荟萃分析旨在总结评估这种关联的横断面和前瞻性队列研究的现有证据。检索了MEDLINE、EMBASE和PsycINFO数据库中截至2012年1月发表的文章。横断面和队列研究报告了两种情况在成人之间的关联。作者提取或提供了患病率、发病率、未调整或调整的比值比（or）和95% CI的数据。采用随机效应模型分别计算横断面研究和队列研究的合并OR。I2统计量用于评估异质性。检索得到29项横断面研究（n = 155,333）： 27项研究报告未调整OR，合并估计为1.42 (95% CI 1.28-1.57; I2 = 55.1%)；11项研究报告了以抑郁为结局的调整OR (1.27 [1.07-1.57], I2 = 60.9%)， 12项研究报告了以MetS为结局的调整OR （1.34 [1.18-1.51], I2 = 0%）。共发现11项队列研究（2项研究双向报道）：9项研究（n = 26,936例，2,316例新发抑郁症患者）报道以抑郁为结局的调整OR (1.49 [1.19-1.87]; I2 = 56.8%)， 4项研究（n = 3,834例，350例MetS患者）报道以MetS为结局的调整OR （1.52 [1.20-1.91]; I2 = 0%）。我们的研究结果表明抑郁症和MetS之间存在双向关联。这些结果支持在MetS患者中早期发现和管理抑郁症，反之亦然。
Epidemiological studies have repeatedly investigated the association between depression and metabolic syndrome (MetS). However, the results have been inconsistent. This meta-analysis aimed to summarize the current evidence from cross-sectional and prospective cohort studies that evaluated this association. MEDLINE, EMBASE, and PsycINFO databases were searched for articles published up to January 2012. Cross-sectional and cohort studies that reported an association between the two conditions in adults were included. Data on prevalence, incidence, unadjusted or adjusted odds ratio (OR), and 95% CI were extracted or provided by the authors. The pooled OR was calculated separately for cross-sectional and cohort studies using random-effects models. The I2 statistic was used to assess heterogeneity. The search yielded 29 cross-sectional studies (n = 155,333): 27 studies reported unadjusted OR with a pooled estimate of 1.42 (95% CI 1.28–1.57; I2 = 55.1%); 11 studies reported adjusted OR with depression as the outcome (1.27 [1.07–1.57]; I2 = 60.9%), and 12 studies reported adjusted OR with MetS as the outcome (1.34 [1.18–1.51]; I2 = 0%). Eleven cohort studies were found (2 studies reported both directions): 9 studies (n = 26,936 with 2,316 new-onset depression case subjects) reported adjusted OR with depression as the outcome (1.49 [1.19–1.87]; I2 = 56.8%), 4 studies (n = 3,834 with 350 MetS case subjects) reported adjusted OR with MetS as the outcome (1.52 [1.20–1.91]; I2 = 0%). Our results indicate a bidirectional association between depression and MetS. These results support early detection and management of depression among patients with MetS and vice versa.
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影响因子：
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作者：
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