Effects of Consuming Xylitol on Gut Microbiota and Lipid Metabolism in Mice.
Effects of Consuming Xylitol on Gut Microbiota and Lipid Metabolism in Mice.
复制标题
DOI：
10.3390/nu9070756
复制
发表时间：
2017-07-14
期刊：
影响因子：
5.9
通讯作者：
Takahashi A
中科院分区：
文献类型：
--
作者：
Uebanso T;Kano S;Yoshimoto A;Naito C;Shimohata T;Mawatari K;Takahashi A
糖醇木糖醇抑制一些细菌物种的生长，包括变形链球菌。它被用作食品添加剂，以防止龋齿。我们之前表明，作为高脂饮食（HFD）的一部分，1.5-4.0 g/kg体重/天的木糖醇可改善大鼠的脂质代谢。然而，较低日剂量的膳食木糖醇对肠道微生物群和脂质代谢的影响尚不清楚。我们研究了40和200 mg/kg体重/天木糖醇摄入量对小鼠肠道微生物群和脂质代谢的影响。通过变性梯度凝胶电泳和靶向实时PCR表征细菌组合物。管腔代谢物测定毛细管电泳电喷雾电离飞行时间质谱。检测血脂和糖耐量。膳食补充低剂量或中剂量木糖醇（分别为40或194 mg/kg体重/天）显著改变了小鼠的粪便微生物群组成。相对于未喂食木糖醇的小鼠，在实验小鼠中向常规和HFD中添加中等剂量木糖醇减少了粪便拟杆菌门和巴内氏菌属的丰度，而在喂食具有中等剂量膳食木糖醇的HFD的小鼠中，厚壁菌门和普雷沃氏菌属的丰度增加。身体组成，肝脏和血清脂质参数，口服葡萄糖耐量，和鲁米那代谢产物不受木糖醇消费。在小鼠中，饮食中40和194 mg/kg体重/天的木糖醇诱导肠道微生物群逐渐变化，但不影响脂质代谢。
The sugar alcohol xylitol inhibits the growth of some bacterial species including Streptococcus mutans. It is used as a food additive to prevent caries. We previously showed that 1.5–4.0 g/kg body weight/day xylitol as part of a high-fat diet (HFD) improved lipid metabolism in rats. However, the effects of lower daily doses of dietary xylitol on gut microbiota and lipid metabolism are unclear. We examined the effect of 40 and 200 mg/kg body weight/day xylitol intake on gut microbiota and lipid metabolism in mice. Bacterial compositions were characterized by denaturing gradient gel electrophoresis and targeted real-time PCR. Luminal metabolites were determined by capillary electrophoresis electrospray ionization time-of-flight mass spectrometry. Plasma lipid parameters and glucose tolerance were examined. Dietary supplementation with low- or medium-dose xylitol (40 or 194 mg/kg body weight/day, respectively) significantly altered the fecal microbiota composition in mice. Relative to mice not fed xylitol, the addition of medium-dose xylitol to a regular and HFD in experimental mice reduced the abundance of fecal Bacteroidetes phylum and the genus Barnesiella, whereas the abundance of Firmicutes phylum and the genus Prevotella was increased in mice fed an HFD with medium-dose dietary xylitol. Body composition, hepatic and serum lipid parameters, oral glucose tolerance, and luminal metabolites were unaffected by xylitol consumption. In mice, 40 and 194 mg/kg body weight/day xylitol in the diet induced gradual changes in gut microbiota but not in lipid metabolism.
登录
查看更多内容
影响因子：
2.4
作者：
Amo K;Arai H;Uebanso T;Fukaya M;Koganei M;Sasaki H;Yamamoto H;Taketani Y;Takeda E
通讯作者：
Takeda E
肠道菌群通过短链脂肪酸受体GPR43抑制胰岛素介导的脂肪积累。
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
3.4
作者：
Campus, Guglielmo;Cagetti, Maria Grazia;Lingstrom, Peter
通讯作者：
Lingstrom, Peter