Raphe-Hippocampal Serotonin Neurotransmission In The Sex Related Differences of Adaptation to Stress: Focus on Serotonin-1A Receptor.
Raphe-Hippocampal Serotonin Neurotransmission In The Sex Related Differences of Adaptation to Stress: Focus on Serotonin-1A Receptor.
复制标题
DOI：
10.2174/157015911796558019
复制
发表时间：
2011-09
影响因子：
5.3
通讯作者：
Jabeen Haleem D
中科院分区：
文献类型：
--
作者：
Jabeen Haleem D
压力是抑郁症发病的主要诱因和促发因素，而抑郁症是妇女最严重的心理健康风险。动物模型的行为研究表明，雌性虽然受急性应激源的影响较小；暴露于反复的压力源会导致应对缺陷，从而损害他们的适应能力。抑郁症患者海马中5-羟色胺（5-HT； 5-羟色胺）功能的下降和中脑核中5-HT- 1a受体功能的增加并存。药理学和神经化学数据表明，由于体树突5-HT1A受体的脱敏，经海马的5-羟色胺神经传递的促进可能导致对应激的适应。本文综述了rape -海马血清素神经传递的性别差异研究，以寻找临床前研究中报道的压力适应的性别差异和女性抑郁症发生率高于男性的可能答案。
Stress is the major predisposing and precipitating factor in the onset of depression which is the most significant mental health risk for women. Behavioral studies in animal models show that female sex though less affected by an acute stressor; exposure to repeated stressors induces coping deficits to impair adaptation in them. A decrease in the function of 5-hydroxytryptamine (5-HT; serotonin) in the hippocampus and an increased function of the 5-HT-1A receptor in the raphe nucleus coexist in depression. Pharmacological and neurochemical data are relevant that facilitation of serotonin neurotransmission via hippocampus due to desensitization of somatodendritic 5-HT1A receptors may lead to adaptation to stress. The present article reviews research on sex related differences of raphe-hippocampal serotonin neurotransmission to find a possible answer that may account for the sex differences of adaptation to stress reported in preclinical research and greater incidence of depression in women than men.
登录
查看更多内容
影响因子：
8.2
作者：
Barros, HMT;Ferigolo, M
通讯作者：
Ferigolo, M
影响因子：
5.3
作者：
David, SP;Murthy, NV;Grasby, PM
通讯作者：
Grasby, PM
影响因子：
3.3
作者：
CARLSSON, M;SVENSSON, K;CARLSSON, A
通讯作者：
CARLSSON, A
影响因子：
4.7
作者：
CURZON, G;JOSEPH, MH;KNOTT, PJ
通讯作者：
KNOTT, PJ
影响因子：
3.3
作者：
Dalla, C;Antoniou, K;Papadopoulou-Daifoti, Z
通讯作者：
Papadopoulou-Daifoti, Z