Cholecystokinin revisited: CCK and the hunger trap in anorexia nervosa.
Cholecystokinin revisited: CCK and the hunger trap in anorexia nervosa.
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DOI：
10.1371/journal.pone.0054457
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Otto B
中科院分区：
文献类型：
--
作者：
Cuntz U;Enck P;Frühauf E;Lehnert P;Riepl RL;Fichter MM;Otto B
尽管在过去的几十年里进行了大量的研究，但CCK在神经性厌食症(AN)中的作用仍然不确定。在这项研究中，对CCK的生物活性部分进行了高度特异性的检测，并对暴食症患者和在体重增加过程中进行跟踪的限制性AN患者进行了检测。对10名受限AN患者和13名暴食症AN患者在入院时(T0)、在连续两个称重日期(T1)体重增加至少2公斤后以及在专科诊所住院治疗出院前最后一周(T2)进行了调查。在禁食条件下以及标准餐(250千卡)后20分钟和60分钟抽取血样。数据与性别和年龄匹配的8名对照组的数据进行了比较。在每个随访时间点通过问卷调查患者的胃肠道主诉。入院时，患者在试餐前后的CCK水平与对照组相似。餐前和餐后CCK水平在最初体重增加后显着增加，但随着体重的进一步改善再次下降。暴食症患者的CCK释放略低于限制性A型患者，但两个亚组表现出相似的特征。CCK释放与初始体重或BMI或它们的变化没有显著关联，但入院时的CCK水平预示着治疗期间胃肠道症状的改善。入院时正常的CCK曲线表明荷尔蒙反应适应了低食物摄入量，而饮食习惯的改变和体重增加导致最初CCK释放增加(抵消了改变饮食行为的尝试)，通过持续治疗恢复到正常水平。
Despite a number of studies in the past decades, the role of Cholecystokinin (CCK) in anorexia nervosa (AN) has remained uncertain. In this study a highly specific assay for the biologically active part of CCK was used in patients with bulimic as well as with the restricting type of AN who were followed over the course of weight gain. Ten patients with restricting and 13 with bulimic AN were investigated upon admission (T0), after a weight gain of at least 2 kg on two consecutive weighting dates (T1), and during the last week before discharge (T2) from inpatient treatment in a specialized clinic. Blood samples were drawn under fasting conditions and 20 and 60 minutes following a standard meal (250 kcal). Data were compared to those of eight controls matched for sex and age. Gastrointestinal complaints of patients were measured by a questionnaire at each of the follow-up time points. At admission, AN patients exhibited CCK-levels similar to controls both prior to and after a test meal. Pre and post-meal CCK levels increased significantly after an initial weight gain but decreased again with further weight improvement. CCK release was somewhat lower in bulimic than in restricting type AN but both subgroups showed a similar profile. There was no significant association of CCK release to either initial weight or BMI, or their changes, but CCK levels at admission predicted gastrointestinal symptom improvement during therapy. Normal CCK profiles in AN at admission indicates hormonal responses adapted to low food intake while change of eating habits and weight gain results in initially increased CCK release (counteracting the attempts to alter eating behavior) that returns towards normal levels with continuous therapy.
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影响因子：
7.1
作者：
Devlin, MJ;Walsh, BT;Petkova, E
通讯作者：
Petkova, E
影响因子：
--
作者：
HARTY, RF;PEARSON, PH;MCGUIGAN, JE
通讯作者：
MCGUIGAN, JE
DOI：
10.1152/ajpregu.2000.278.4.r882
发表时间：
2000-04-01
影响因子：
2.8
作者：
Matson, CA;Reid, DF;Ritter, RC
通讯作者：
Ritter, RC
DOI：
10.1037/h0034870
发表时间：
1973-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
GIBBS, J;YOUNG, RC;SMITH, GP
通讯作者：
SMITH, GP
影响因子：
--
作者：
GREEN, GM;LEVAN, VH;LIDDLE, RA
通讯作者：
LIDDLE, RA